Insulin: Difference between revisions
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<StructureSection load='' size='350' side='right' scene='82/821037/Ribbon/1' caption=''> | <StructureSection load='' size='350' side='right' scene='82/821037/Ribbon/1' caption=''> | ||
===Structure of mature insulin monomer=== | ===Structure of mature insulin monomer=== | ||
<scene name='82/821037/Ribbon/1'>Mature insulin</scene> contains two chains, A and B, held together by disulfide bonds and non-covalent interactions. The <scene name='82/821037/Spacefilling/2'>surface of insulin</scene> contains quite a few hydrophobic side chains, which form protein:protein contacts when insulin forms hexamers or binds to its receptor. Select coloring of the side chains below to explore the surface properties. | <scene name='82/821037/Ribbon/1'>Mature insulin</scene> contains two chains, A and B, held together by disulfide bonds and non-covalent interactions. This structure, determined by Dorothy Hodgkin in 1969 using X-ray crystallography, was one of the [[Highest_impact_structures|first protein structures]] to be solved. The <scene name='82/821037/Spacefilling/2'>surface of insulin</scene> contains quite a few hydrophobic side chains, which form protein:protein contacts when insulin forms hexamers or binds to its receptor. Select coloring of the side chains below to explore the surface properties. | ||
Sidechains colored by <jmol> | Sidechains colored by <jmol> | ||
