6mr4: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

The ~~entry 6mr4~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Crystal structure of the Sth1 bromodomain from S.cerevisiae==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6mr4]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MR4 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MR4 FirstGlance].

~~Description~~:

</td></tr><tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/DNA_helicase DNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.12 3.6.4.12] </td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mr4 OCA], [http://pdbe.org/6mr4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mr4 RCSB], [http://www.ebi.ac.uk/pdbsum/6mr4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mr4 ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/STH1_YEAST STH1_YEAST]] Catalytic component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is the essential ATPase of the complex. It is a DNA translocase capable of nucleosome remodeling. Required for full expression of early meiotic genes. Essential for mitotic growth and repression of CHA1 expression. Also involved in G2 phase control.<ref>PMID:10025404</ref> <ref>PMID:10320476</ref> <ref>PMID:10329629</ref> <ref>PMID:12072455</ref> <ref>PMID:12183366</ref> <ref>PMID:12697820</ref> <ref>PMID:8980231</ref> <ref>PMID:9799253</ref>

== References ==

__TOC__

</StructureSection>

[[Category: DNA helicase]]

[[Category: Large Structures]]

[[Category: Blus, B J]]

[[Category: Debler, E W]]

[[Category: Hashimoto, H]]

[[Category: Krolak, A]]

[[Category: Seo, H S]]

[[Category: Acetylated-lysine histone binding]]

[[Category: Bromodomain]]

[[Category: Chromatin structure]]

[[Category: Gene expression]]

[[Category: Gene regulation]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6mr4 is ON HOLD  until Paper Publication
+==Crystal structure of the Sth1 bromodomain from S.cerevisiae==
+<StructureSection load='6mr4' size='340' side='right'caption='[[6mr4]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6mr4]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MR4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MR4 FirstGlance]. <br>
-Description:
+</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_helicase DNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.12 3.6.4.12] </span></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mr4 OCA], [http://pdbe.org/6mr4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mr4 RCSB], [http://www.ebi.ac.uk/pdbsum/6mr4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mr4 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/STH1_YEAST STH1_YEAST]] Catalytic component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is the essential ATPase of the complex. It is a DNA translocase capable of nucleosome remodeling. Required for full expression of early meiotic genes. Essential for mitotic growth and repression of CHA1 expression. Also involved in G2 phase control.<ref>PMID:10025404</ref> <ref>PMID:10320476</ref> <ref>PMID:10329629</ref> <ref>PMID:12072455</ref> <ref>PMID:12183366</ref> <ref>PMID:12697820</ref> <ref>PMID:8980231</ref> <ref>PMID:9799253</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: DNA helicase]]
+[[Category: Large Structures]]
+[[Category: Blus, B J]]
+[[Category: Debler, E W]]
+[[Category: Hashimoto, H]]
+[[Category: Krolak, A]]
+[[Category: Seo, H S]]
+[[Category: Acetylated-lysine histone binding]]
+[[Category: Bromodomain]]
+[[Category: Chromatin structure]]
+[[Category: Gene expression]]
+[[Category: Gene regulation]]