2wt0

Galectin domain of porcine adenovirus type 4 NADC-1 isolate fibre complexed with N-acetyl-lactosamine

spinqualitylabelsall models 2wt0, resolution 1.91Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2wt0 is a 1 chain structure with sequence from Adep4. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: GAL, NAG, NO3 Related: 2wt1, 2wsv, 2wsu, 2wst, 2wt2 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Adenovirus isolate NADC-1, a strain of porcine adenovirus type 4, has a fiber containing an N-terminal virus attachment region, shaft and head domains, and a C-terminal galectin domain connected to the head by an RGD-containing sequence. The crystal structure of the head domain is similar to previously solved adenovirus fiber head domains, but specific residues for binding the coxsackievirus and adenovirus receptor (CAR), CD46, or sialic acid are not conserved. The structure of the galectin domain reveals an interaction interface between its two carbohydrate recognition domains, locating both sugar binding sites face to face. Sequence evidence suggests other tandem-repeat galectins have the same arrangement. We show that the galectin domain binds carbohydrates containing lactose and N-acetyl-lactosamine units, and we present structures of the galectin domain with lactose, N-acetyl-lactosamine, 3-aminopropyl-lacto-N-neotetraose, and 2-aminoethyl-tri(N-acetyl-lactosamine), confirming the domain as a bona fide galectin domain. Crystallographic structure of porcine adenovirus type 4 fiber head and galectin domains.,Guardado-Calvo P, Munoz EM, Llamas-Saiz AL, Fox GC, Kahn R, Curiel DT, Glasgow JN, van Raaij MJ J Virol. 2010 Oct;84(20):10558-68. Epub 2010 Aug 4. PMID:20686025 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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