1n93

Crystal Structure of the Borna Disease Virus Nucleoprotein

spinqualitylabelsall models 1n93, resolution 1.76Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1n93 is a 1 chain structure with sequence from Bdv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [WNCAP_BDV] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. Targets viral NC to the nucleus. Could be involved in the transport of nucleoprotein particles from the nucleus to the cytoplasm. The nuclear export signal is masked by the interaction with the P protein. Publication Abstract from PubMed Borna disease virus (BDV) causes an infection of the central nervous system in a wide range of vertebrates, which can fatally progress to an immune-mediated disease, called Borna disease. BDV is a member of the Mononegavirales, which also includes the highly infectious measles and Ebola viruses. The viral nucleoproteins are central to transcription, replication, and packaging of the RNA genome. We present the X-ray structure of the BDV nucleoprotein determined at 1.76 A resolution. The structure reveals a novel fold, organized into two distinct domains, and an assembly into a planar homotetramer. Surface potential calculations strongly support an RNA binding model with the RNA wrapping around the outside of the tetramer, although a positively charged central channel in the tetramer could fit single-stranded RNA in an alternative binding mode. This first structure of an RNA virus nucleoprotein provides a paradigmatic model for RNA packaging and replication of single-stranded RNA viruses. Crystal structure of the borna disease virus nucleoprotein.,Rudolph MG, Kraus I, Dickmanns A, Eickmann M, Garten W, Ficner R Structure. 2003 Oct;11(10):1219-26. PMID:14527390 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Nucleoprotein

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