5qra: Difference between revisions

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'''Unreleased structure'''


The entry 5qra is ON HOLD
==PanDDA analysis group deposition -- Crystal Structure of human ALAS2A in complex with Z1101755952==
 
<StructureSection load='5qra' size='340' side='right'caption='[[5qra]], [[Resolution|resolution]] 1.72&Aring;' scene=''>
Authors: Bezerra, G.A., Foster, W., Bailey, H., Shrestha, L., Krojer, T., Talon, R., Brandao-Neto, J., Douangamath, A., Nicola, B.B., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Brennan, P.E., Yue, W.W.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5qra]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QRA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5QRA FirstGlance]. <br>
Description: PanDDA analysis group deposition --Crystal Structure of human ALAS2A in complex with Z1101755952
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NVM:[(4R)-4-methyl-2,3,4,5-tetrahydro-1H-azepin-1-yl](1,3-thiazol-4-yl)methanone'>NVM</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5-aminolevulinate_synthase 5-aminolevulinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.37 2.3.1.37] </span></td></tr>
[[Category: Foster, W]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5qra FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qra OCA], [http://pdbe.org/5qra PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qra RCSB], [http://www.ebi.ac.uk/pdbsum/5qra PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qra ProSAT]</span></td></tr>
[[Category: Arrowsmith, C.H]]
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/HEM0_HUMAN HEM0_HUMAN]] X-linked sideroblastic anemia;Erythropoietic protoporphyria. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry. Gain of function mutations in ALS2 are responsible for XLDPT, but they can also be a possible aggravating factor in congenital erythropoietic porphyria and other erythropoietic disorders caused by mutations in other genes (PubMed:21309041).<ref>PMID:21309041</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: 5-aminolevulinate synthase]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Bailey, H]]
[[Category: Bezerra, G A]]
[[Category: Bountra, C]]
[[Category: Brandao-Neto, J]]
[[Category: Brandao-Neto, J]]
[[Category: Talon, R]]
[[Category: Brennan, P E]]
[[Category: Brennan, P.E]]
[[Category: Delft, F von]]
[[Category: Shrestha, L]]
[[Category: Douangamath, A]]
[[Category: Bezerra, G.A]]
[[Category: Edwards, A]]
[[Category: Edwards, A]]
[[Category: Nicola, B.B]]
[[Category: Foster, W]]
[[Category: Douangamath, A]]
[[Category: Krojer, T]]
[[Category: Krojer, T]]
[[Category: Yue, W.W]]
[[Category: Nicola, B B]]
[[Category: Von Delft, F]]
[[Category: Shrestha, L]]
[[Category: Bailey, H]]
[[Category: Talon, R]]
[[Category: Bountra, C]]
[[Category: Yue, W W]]
[[Category: Pandda]]
[[Category: Sgc - diamond i04-1 fragment screening]]
[[Category: Transferase]]
[[Category: Xchemexplorer]]
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