6myn: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6myn is ~~ON HOLD until Paper Publication~~

==Crystal structure of murine NF-kappaB inducing kinase (NIK) bound to inhibitor R7==

~~Authors~~: ~~Harris~~, S.F., ~~Smith~~, M., ~~Barker~~, J.

== Structural highlights ==

<table><tr><td colspan='2'>[[6myn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MYN OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MYN FirstGlance].

~~Description~~: ~~Crystal structure~~ of ~~murine~~ NF-~~kappaB inducing kinase (NIK) bound~~ to ~~inhibitor R7~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=K6Y:(5s,7s)-9-fluoro-10-[(3R)-3-hydroxy-3-(5-methyl-1,2-oxazol-3-yl)but-1-yn-1-yl]-N~3~-methyl-6,7-dihydro-5H-5,7-methanoimidazo[2,1-a][2]benzazepine-2,3-dicarboxamide'>K6Y</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4g3c|4g3c]]</td></tr>

[[Category: ~~Harris, S.F~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase_kinase_kinase Mitogen-activated protein kinase kinase kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.25 2.7.11.25] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6myn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6myn OCA], [http://pdbe.org/6myn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6myn RCSB], [http://www.ebi.ac.uk/pdbsum/6myn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6myn ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/M3K14_MOUSE M3K14_MOUSE]] Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner.<ref>PMID:11239468</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Mitogen-activated protein kinase kinase kinase]]

[[Category: Barker, J]]

[[Category: Harris, S F]]

[[Category: Smith, M]]

[[Category: Kinase]]

[[Category: Nik]]

[[Category: Transferase]]

[[Category: Transferase-transferase inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6myn is ON HOLD  until Paper Publication
+==Crystal structure of murine NF-kappaB inducing kinase (NIK) bound to inhibitor R7==
+<StructureSection load='6myn' size='340' side='right'caption='[[6myn]], [[Resolution|resolution]] 2.74&Aring;' scene=''>
-Authors: Harris, S.F., Smith, M., Barker, J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6myn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MYN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MYN FirstGlance]. <br>
-Description: Crystal structure of murine NF-kappaB inducing kinase (NIK) bound to inhibitor R7
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K6Y:(5s,7s)-9-fluoro-10-[(3R)-3-hydroxy-3-(5-methyl-1,2-oxazol-3-yl)but-1-yn-1-yl]-N~3~-methyl-6,7-dihydro-5H-5,7-methanoimidazo[2,1-a][2]benzazepine-2,3-dicarboxamide'>K6Y</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4g3c|4g3c]]</td></tr>
-[[Category: Harris, S.F]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase_kinase_kinase Mitogen-activated protein kinase kinase kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.25 2.7.11.25] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6myn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6myn OCA], [http://pdbe.org/6myn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6myn RCSB], [http://www.ebi.ac.uk/pdbsum/6myn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6myn ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/M3K14_MOUSE M3K14_MOUSE]] Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner.<ref>PMID:11239468</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Mitogen-activated protein kinase kinase kinase]]
 [[Category: Barker, J]]
+[[Category: Harris, S F]]
 [[Category: Smith, M]]
+[[Category: Kinase]]
+[[Category: Nik]]
+[[Category: Transferase]]
+[[Category: Transferase-transferase inhibitor complex]]