6nfv: Difference between revisions
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==Structure of the KcsA-G77C mutant or the 2,4-ion bound configuration of a K+ channel selectivity filter.== | |||
<StructureSection load='6nfv' size='340' side='right'caption='[[6nfv]], [[Resolution|resolution]] 2.13Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6nfv]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NFV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NFV FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1EM:(1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL+MYRISTATE'>1EM</scene>, <scene name='pdbligand=F09:NONAN-1-OL'>F09</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nfv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nfv OCA], [http://pdbe.org/6nfv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nfv RCSB], [http://www.ebi.ac.uk/pdbsum/6nfv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nfv ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI]] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Cortes, D M]] | |||
[[Category: Cuello, L G]] | |||
[[Category: Guan, L]] | |||
[[Category: Hardy, E]] | |||
[[Category: Jahovic, N]] | |||
[[Category: Parameswaran, H]] | [[Category: Parameswaran, H]] | ||
[[Category: Tilegenova, C]] | [[Category: Tilegenova, C]] | ||
[[Category: Ion channel]] | |||
[[Category: Membrane protein]] | |||
[[Category: Membrane transport]] | |||
[[Category: Metal transport]] | |||
[[Category: Potassium channel]] | |||
Revision as of 05:55, 7 August 2019
Structure of the KcsA-G77C mutant or the 2,4-ion bound configuration of a K+ channel selectivity filter.
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