6s29: Difference between revisions
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==Structure of fission yeast Mis16-Mis19 complex== | |||
<StructureSection load='6s29' size='340' side='right'caption='[[6s29]], [[Resolution|resolution]] 1.99Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6s29]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S29 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6S29 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6s29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s29 OCA], [http://pdbe.org/6s29 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s29 RCSB], [http://www.ebi.ac.uk/pdbsum/6s29 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s29 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/HAT2_SCHPO HAT2_SCHPO]] Regulatory subunit of the histone acetylase B (HAT-B) complex (By similarity). The complex acetylates 'Lys-12' of histone H4 which is required for telomeric silencing (By similarity). Component of the CENP-A recruiting complex that ensures the integrity of mitotic spindles through maintenance of kinetochore factors mis6/CENP-I and cnp1/CENP-A (PubMed:15369671, PubMed:24774534, PubMed:24789708, PubMed:25375240). Maintains the deacetylated state of histones specifically in the central core of the centromeres (PubMed:15369671).[UniProtKB:P39984]<ref>PMID:15369671</ref> <ref>PMID:24774534</ref> <ref>PMID:24789708</ref> <ref>PMID:25375240</ref> [[http://www.uniprot.org/uniprot/MIS19_SCHPO MIS19_SCHPO]] Component of the CENP-A recruiting complex that ensures the integrity of mitotic spindles through maintenance of kinetochore factors mis6/CENP-I and cnp1/CENP-A (PubMed:24774534, PubMed:24789708, PubMed:25375240). Links mis16 and mis18 to recruit CENP-A through interacting with non-sense-mediated mRNA decay (NMD) factors and the SWI/SNF complex (PubMed:24774534). Links also mis18 with the CCAN/mis6/ctf19 complex to promote CENP-A assembly (PubMed:24789708).<ref>PMID:24774534</ref> <ref>PMID:24789708</ref> <ref>PMID:25375240</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Korntner-Vetter, M]] | |||
[[Category: Lefevre, S]] | |||
[[Category: Singleton, M R]] | |||
[[Category: Cell cycle]] | |||
[[Category: Centromere mitosis wd40 histone chaperone]] | |||
Revision as of 06:07, 7 August 2019
Structure of fission yeast Mis16-Mis19 complex
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