6htn: Difference between revisions
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==Structure of a fucose lectin from Kordia zhangzhouensis in complex with methyl-fucoside== | |||
<StructureSection load='6htn' size='340' side='right'caption='[[6htn]], [[Resolution|resolution]] 1.55Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6htn]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Dsm_25731 Dsm 25731]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HTN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HTN FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MFU:ALPHA-L-METHYL-FUCOSE'>MFU</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=PE8:3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL'>PE8</scene></td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">C8N46_102337 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=701523 DSM 25731])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6htn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6htn OCA], [http://pdbe.org/6htn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6htn RCSB], [http://www.ebi.ac.uk/pdbsum/6htn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6htn ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Lectins with a beta-propeller fold bind glycans on the cell surface through multivalent binding sites and appropriate directionality. These proteins are formed by repeats of short domains, raising questions about evolutionary duplication. However, these repeats are difficult to detect in translated genomes and seldom correctly annotated in sequence databases. To address these issues, we defined the blade signature of the five types of beta-propellers using 3D-structural data. With these templates, we predicted 3,887 beta-propeller lectins in 1,889 species and organized this information in a searchable online database. The data reveal a widespread distribution of beta-propeller lectins across species. Prediction also emphasizes multiple architectures and led to the discovery of a beta-propeller assembly scenario. This was confirmed by producing and characterizing a predicted protein coded in the genome of Kordia zhangzhouensis. The crystal structure uncovers an intermediate in the evolution of beta-propeller assembly and demonstrates the power of our tools. | |||
Architecture and Evolution of Blade Assembly in beta-propeller Lectins.,Bonnardel F, Kumar A, Wimmerova M, Lahmann M, Perez S, Varrot A, Lisacek F, Imberty A Structure. 2019 May 7;27(5):764-775.e3. doi: 10.1016/j.str.2019.02.002. Epub 2019, Mar 7. PMID:30853410<ref>PMID:30853410</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 6htn" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Dsm 25731]] | |||
[[Category: Large Structures]] | |||
[[Category: Varrot, A]] | [[Category: Varrot, A]] | ||
[[Category: Fucose binding]] | |||
[[Category: Lectin]] | |||
[[Category: Propeller]] | |||
[[Category: Sugar binding protein]] | |||
