3p49

Crystal Structure of a Glycine Riboswitch from Fusobacterium nucleatum

spinqualitylabelsall models 3p49, resolution 3.55Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3p49 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: GLY, MG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [SNRPA_HUMAN] Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro. Publication Abstract from PubMed The glycine riboswitch regulates gene expression through the cooperative recognition of its amino acid ligand by a tandem pair of aptamers. A 3.6 A crystal structure of the tandem riboswitch from the glycine permease operon of Fusobacterium nucleatum reveals the glycine binding sites and an extensive network of interactions, largely mediated by asymmetric A-minor contacts, that serve to communicate ligand binding status between the aptamers. These interactions provide a structural basis for how the glycine riboswitch cooperatively regulates gene expression. Structural basis of cooperative ligand binding by the glycine riboswitch.,Butler EB, Xiong Y, Wang J, Strobel SA Chem Biol. 2011 Mar 25;18(3):293-8. PMID:21439473 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Nucleoprotein Riboswitch

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