6ecj: Difference between revisions

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'''Unreleased structure'''


The entry 6ecj is ON HOLD  until Paper Publication
==Human cytochrome c G41T==
 
<StructureSection load='6ecj' size='340' side='right'caption='[[6ecj]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
Authors: Fellner, M., Jameson, G.N.L., Ledgerwood, E.C., Wilbanks, S.M.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6ecj]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ECJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ECJ FirstGlance]. <br>
Description: Human cytochrome c G41T
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ecj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ecj OCA], [http://pdbe.org/6ecj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ecj RCSB], [http://www.ebi.ac.uk/pdbsum/6ecj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ecj ProSAT]</span></td></tr>
[[Category: Ledgerwood, E.C]]
</table>
[[Category: Jameson, G.N.L]]
== Disease ==
[[Category: Wilbanks, S.M]]
[[http://www.uniprot.org/uniprot/CYC_HUMAN CYC_HUMAN]] Defects in CYCS are the cause of thrombocytopenia type 4 (THC4) [MIM:[http://omim.org/entry/612004 612004]]; also known as autosomal dominant thrombocytopenia type 4. Thrombocytopenia is the presence of relatively few platelets in blood. THC4 is a non-syndromic form of thrombocytopenia. Clinical manifestations of thrombocytopenia are absent or mild. THC4 may be caused by dysregulated platelet formation.<ref>PMID:18345000</ref> 
== Function ==
[[http://www.uniprot.org/uniprot/CYC_HUMAN CYC_HUMAN]] Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.  Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Fellner, M]]
[[Category: Fellner, M]]
[[Category: Jameson, G N.L]]
[[Category: Ledgerwood, E C]]
[[Category: Wilbanks, S M]]
[[Category: Apoptosis]]
[[Category: Cytochrome c]]
[[Category: Glycine to threonine substitution]]
[[Category: Heme]]
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