6jjj: Difference between revisions

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'''Unreleased structure'''


The entry 6jjj is ON HOLD  until Paper Publication
==Trimeric structure of Kupffer cell C-type lectin receptor Clec4f==
<StructureSection load='6jjj' size='340' side='right'caption='[[6jjj]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6jjj]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JJJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JJJ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jjj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jjj OCA], [http://pdbe.org/6jjj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jjj RCSB], [http://www.ebi.ac.uk/pdbsum/6jjj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jjj ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/CLC4F_MOUSE CLC4F_MOUSE]] Receptor with an affinity for galactose and fucose. Could be involved in endocytosis.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The C-type lectin receptor Clec4f has been identified as a specific surface marker for Kupffer cells, although its ortholog is absent in humans and its biological function remains elusive. Here, we report the crystal structure of a truncated mouse trimeric Clec4f. The orientation between the carbohydrate-recognition domain of Clec4f and its neck region differs from other C-type lectins, resulting in an observed distance of 45 A between the glycan-binding sites within the Clec4f trimer. Interestingly, the trimeric coiled-coil interface within its heptad neck region contains multiple polyglutamine interactions instead of the predominantly hydrophobic leucine zipper found in other C-type lectin receptors. The Clec4f trimeric structure displays unique features regarding its assembly and ligand recognition, shedding light on the evolution and diversity of the C-type lectin family.


Authors:  
Trimeric structure of the mouse Kupffer cell C-type lectin receptor Clec4f.,Ouyang Z, Felix J, Zhou J, Pei Y, Ma B, Hwang PM, Lemieux MJ, Gutsche I, Zheng F, Wen Y FEBS Lett. 2019 Aug 1. doi: 10.1002/1873-3468.13565. PMID:31369681<ref>PMID:31369681</ref>


Description:  
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
<div class="pdbe-citations 6jjj" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Felix, J]]
[[Category: Ouyang, Z]]
[[Category: Wen, Y]]
[[Category: C-type lectin receptor]]
[[Category: Clec4f]]
[[Category: Kupffer cell receptor]]
[[Category: Sugar binding protein]]
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