6agk: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

The ~~entry~~ 6agk is ~~ON HOLD until Paper Publication~~

==The structure of CH-II-77-tubulin complex==

~~Authors~~: ~~Chen~~, H., ~~Arnst~~, K., ~~Wang~~, Y., ~~Miller~~, D., ~~Li, W~~.

== Structural highlights ==

<table><tr><td colspan='2'>[[6agk]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AGK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AGK FirstGlance]. <br>

~~Description~~: ~~The structure~~ of CH-II-~~77-tubulin complex~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9WR:[6-(3-hydroxy-4-methylphenyl)pyridin-2-yl](3,4,5-trimethoxyphenyl)methanone'>9WR</scene>, <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6agk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6agk OCA], [http://pdbe.org/6agk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6agk RCSB], [http://www.ebi.ac.uk/pdbsum/6agk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6agk ProSAT]</span></td></tr>

[[Category: ~~Wang, Y~~]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/TBA1B_PIG TBA1B_PIG]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT]] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref> [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Arnst, K]]

[[Category: Chen, H]]

[[Category: Li, W]]

~~[[Category: Chen, H]]~~

[[Category: Miller, D]]

[[Category: Wang, Y]]

[[Category: Complex]]

[[Category: Inhibitor]]

[[Category: Structural protein]]

[[Category: Tubulin]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6agk is ON HOLD  until Paper Publication
+==The structure of CH-II-77-tubulin complex==
+<StructureSection load='6agk' size='340' side='right'caption='[[6agk]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-Authors: Chen, H., Arnst, K., Wang, Y., Miller, D., Li, W.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6agk]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AGK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AGK FirstGlance]. <br>
-Description: The structure of CH-II-77-tubulin complex
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9WR:[6-(3-hydroxy-4-methylphenyl)pyridin-2-yl](3,4,5-trimethoxyphenyl)methanone'>9WR</scene>, <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6agk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6agk OCA], [http://pdbe.org/6agk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6agk RCSB], [http://www.ebi.ac.uk/pdbsum/6agk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6agk ProSAT]</span></td></tr>
-[[Category: Wang, Y]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/TBA1B_PIG TBA1B_PIG]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT]] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref>  [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Arnst, K]]
+[[Category: Chen, H]]
 [[Category: Li, W]]
-[[Category: Chen, H]]
 [[Category: Miller, D]]
+[[Category: Wang, Y]]
+[[Category: Complex]]
+[[Category: Inhibitor]]
+[[Category: Structural protein]]
+[[Category: Tubulin]]