6eet: Difference between revisions
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==Crystal structure of mouse Protocadherin-15 EC9-MAD12== | |||
<StructureSection load='6eet' size='340' side='right'caption='[[6eet]], [[Resolution|resolution]] 3.23Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6eet]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EET OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EET FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eet FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eet OCA], [http://pdbe.org/6eet PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eet RCSB], [http://www.ebi.ac.uk/pdbsum/6eet PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eet ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/PCD15_MOUSE PCD15_MOUSE]] Defects in Pcdh15 are the cause of the Ames waltzer (av) phenotype. It is characterized by deafness and a balance disorder, associated with the degeneration of inner ear neuroepithelia. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/PCD15_MOUSE PCD15_MOUSE]] Calcium-dependent cell-adhesion protein. Required for inner ear neuroepithelial cell elaboration and cochlear function. Probably involved in the maintenance of normal retinal function. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Narui, Y]] | |||
[[Category: Sotomayor, M]] | |||
[[Category: Calcium binding protein]] | |||
[[Category: Cell adhesion]] | |||
[[Category: Hearing]] | |||
[[Category: Mechanotransduction]] | |||
[[Category: Stereocilia]] | |||
[[Category: Tip link]] | |||
Revision as of 05:50, 21 August 2019
Crystal structure of mouse Protocadherin-15 EC9-MAD12
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