6m8h: Difference between revisions
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==Crystal Structure of the R208Q mutant of G(i) subunit alpha-1== | |||
<StructureSection load='6m8h' size='340' side='right'caption='[[6m8h]], [[Resolution|resolution]] 2.07Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6m8h]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M8H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6M8H FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6m8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m8h OCA], [http://pdbe.org/6m8h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6m8h RCSB], [http://www.ebi.ac.uk/pdbsum/6m8h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6m8h ProSAT]</span></td></tr> | ||
[[ | </table> | ||
[[ | == Function == | ||
[[Category: | [[http://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref> | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Ballicora, M]] | [[Category: Ballicora, M]] | ||
[[Category: Goossens, J]] | [[Category: Goossens, J]] | ||
[[Category: Kothawala, S]] | |||
[[Category: Leverson, B]] | [[Category: Leverson, B]] | ||
[[Category: Liu, D]] | |||
[[Category: Mascarenhas, R]] | [[Category: Mascarenhas, R]] | ||
[[Category: Olsen, K]] | |||
[[Category: Freitas, D de]] | |||
[[Category: G protein]] | |||
[[Category: Oncogenic mutation]] | |||
[[Category: Signaling protein]] | |||
[[Category: Switch ii region]] | |||
Revision as of 05:54, 21 August 2019
Crystal Structure of the R208Q mutant of G(i) subunit alpha-1
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