6s8m: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6s8m is ~~ON HOLD~~

==S. pombe microtubule decorated with Cut7 motor domain in the AMPPNP state==

~~Authors~~: ~~Moores~~, C.A., ~~von Loeffelholz~~, O.

== Structural highlights ==

<table><tr><td colspan='2'>[[6s8m]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S8M OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6S8M FirstGlance].

~~Description~~: S. ~~pombe microtubule decorated with Cut7~~ motor ~~domain in~~ the ~~AMPPNP state~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=EPB:7,11-DIHYDROXY-8,8,10,12,16-PENTAMETHYL-3-[1-METHYL-2-(2-METHYL-THIAZOL-4-YL)VINYL]-4,17-DIOXABICYCLO[14.1.0]HEPTADECANE-5,9-DIONE'>EPB</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[5mlv|5mlv]]</td></tr>

[[Category: ~~Von~~ Loeffelholz, O]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6s8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s8m OCA], [http://pdbe.org/6s8m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s8m RCSB], [http://www.ebi.ac.uk/pdbsum/6s8m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s8m ProSAT]</td></tr>

[[Category: Moores, C.A]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/CUT7_SCHPO CUT7_SCHPO]] Could be a spindle pole body motor. On transition from G2 to M phase of the cell cycle, the spindle pole body duplicates; the daughter pole bodies seed microtubules which interdigitate to form a short spindle that elongates to span the nucleus at metaphase. Mutations at cut7 block spindle formation. [[http://www.uniprot.org/uniprot/TBA1_SCHPO TBA1_SCHPO]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/TBB_SCHPO TBB_SCHPO]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Loeffelholz, O von]]

[[Category: Moores, C A]]

[[Category: Cut7 motor domain]]

[[Category: Kinesin-5]]

[[Category: Microtubule]]

[[Category: Motor protein]]

[[Category: S. pombe]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6s8m is ON HOLD
+==S. pombe microtubule decorated with Cut7 motor domain in the AMPPNP state==
+<StructureSection load='6s8m' size='340' side='right'caption='[[6s8m]], [[Resolution|resolution]] 4.50&Aring;' scene=''>
-Authors: Moores, C.A., von Loeffelholz, O.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6s8m]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S8M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6S8M FirstGlance]. <br>
-Description: S. pombe microtubule decorated with Cut7 motor domain in the AMPPNP state
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=EPB:7,11-DIHYDROXY-8,8,10,12,16-PENTAMETHYL-3-[1-METHYL-2-(2-METHYL-THIAZOL-4-YL)VINYL]-4,17-DIOXABICYCLO[14.1.0]HEPTADECANE-5,9-DIONE'>EPB</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5mlv|5mlv]]</td></tr>
-[[Category: Von Loeffelholz, O]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6s8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s8m OCA], [http://pdbe.org/6s8m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s8m RCSB], [http://www.ebi.ac.uk/pdbsum/6s8m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s8m ProSAT]</span></td></tr>
-[[Category: Moores, C.A]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/CUT7_SCHPO CUT7_SCHPO]] Could be a spindle pole body motor. On transition from G2 to M phase of the cell cycle, the spindle pole body duplicates; the daughter pole bodies seed microtubules which interdigitate to form a short spindle that elongates to span the nucleus at metaphase. Mutations at cut7 block spindle formation. [[http://www.uniprot.org/uniprot/TBA1_SCHPO TBA1_SCHPO]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/TBB_SCHPO TBB_SCHPO]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Loeffelholz, O von]]
+[[Category: Moores, C A]]
+[[Category: Cut7 motor domain]]
+[[Category: Kinesin-5]]
+[[Category: Microtubule]]
+[[Category: Motor protein]]
+[[Category: S. pombe]]