Hydroxysteroid dehydrogenase: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 16: | Line 16: | ||
== Structural highlights == | == Structural highlights == | ||
The structure of 3-α HSD is that of an <scene name='49/491805/Cv/5'>α/β barrel</scene> with the <scene name='49/491805/Cv/6'>cofactor NADP binding site</scene> at the C-terminal of the barrel<ref>PMID:8718859</ref>. Water molecules shown as red spheres. | The structure of 3-α HSD is that of an <scene name='49/491805/Cv/5'>α/β barrel</scene> with the <scene name='49/491805/Cv/6'>cofactor NADP binding site</scene> at the C-terminal of the barrel<ref>PMID:8718859</ref>. Water molecules shown as red spheres. | ||
==3D structures of hydroxysteroid dehydrogenase== | |||
[[Hydroxysteroid dehydrogenase 3D structures]] | |||
</StructureSection> | </StructureSection> | ||
| Line 71: | Line 74: | ||
**[[1q13]] - raHSD + hydroxysteroid + NADP<BR /> | **[[1q13]] - raHSD + hydroxysteroid + NADP<BR /> | ||
*11-β HSD | *11-β HSD or corticosteroid 11-β-dehydrogenase 1 | ||
**[[1xu7]], [[1xu9]] - hHSD (mutant) + NADP<BR /> | **[[1xu7]], [[1xu9]] - hHSD (mutant) + NADP<BR /> | ||
| Line 85: | Line 88: | ||
**[[2bel]] - hHSD 1 + hydroxysteroid + NADP<BR /> | **[[2bel]] - hHSD 1 + hydroxysteroid + NADP<BR /> | ||
**[[2irw]], [[2ilt]], [[4bb5]], [[4bb6]] - hHSD 1 + inhibitor + NADP<BR /> | **[[2irw]], [[2ilt]], [[4bb5]], [[4bb6]] - hHSD 1 + inhibitor + NADP<BR /> | ||
**[[2rbe]], [[3byz]], [[3bzu]], [[3ch6]], [[3czr]], [[3d3e]], [[3d4n]], [[3d5q]], [[3ey4]], [[3frj]], [[3hfg]], [[3fco]], [[3h6k]], [[3oq1]], [[3pdj]], [[3tfq]], [[3qqp]], [[4c7j]], [[4c7k]], [[4p38]] - hHSD 1 (mutant) + inhibitor + NADP<BR /> | **[[2rbe]], [[3byz]], [[3bzu]], [[3ch6]], [[3czr]], [[3d3e]], [[3d4n]], [[3d5q]], [[3ey4]], [[3frj]], [[3hfg]], [[3fco]], [[3h6k]], [[3oq1]], [[3pdj]], [[3tfq]], [[3qqp]], [[4c7j]], [[4c7k]], [[4p38]], [[5pgu]], [[5pgv]], [[5pgw]], [[5pgx]], [[5pgy]], [[5pgz]], [[5pii]], [[5pij]] - hHSD 1 (mutant) + inhibitor + NADP<BR /> | ||
**[[6nj7]] - hHSD 1 + colleic acid + NAP<br /> | |||
**[[3g49]] - gpHSD catalytic domain + inhibitor + NADP<BR /> | **[[3g49]] - gpHSD catalytic domain + inhibitor + NADP<BR /> | ||
**[[1y5r]], [[3gmd]] - mHSD 1 + hydroxysteroid + NADP<BR /> | **[[1y5r]], [[3gmd]] - mHSD 1 + hydroxysteroid + NADP<BR /> | ||
| Line 100: | Line 104: | ||
**[[3cv6]] - mHSD (mutant) + inhibitor + NADP<br /> | **[[3cv6]] - mHSD (mutant) + inhibitor + NADP<br /> | ||
*17-β HSD | *17-β HSD or estradiol 11-β-dehydrogenase 1 | ||
'''For 17-β HSD type 5 or AKR1C3 see''' [[Prostaglandin F synthase]] | '''For 17-β HSD type 5 or AKR1C3 see''' [[Prostaglandin F synthase]] | ||
**[[1bhs | **[[1bhs]] – hHSD 1 <BR /> | ||
**[[1s9c]] - hHSD (mutant) <BR /> | **[[1s9c]] - hHSD 4 (mutant) <BR /> | ||
**[[5ics]] – hHSD 14 <BR /> | |||
**[[3is3]] – ClHSD – ''Cochliobolus lunatus''<BR /> | **[[3is3]] – ClHSD – ''Cochliobolus lunatus''<BR /> | ||
**[[3itd]] - ClHSD (mutant) | **[[3itd]] - ClHSD (mutant) | ||
| Line 111: | Line 116: | ||
*''17-β HSD binary complex'' | *''17-β HSD binary complex'' | ||
**[[1jtv]], [[1yb1]], [[3dhe]], [[1fds]], [[1iol]], [[3klm]], [[3klp]], [[3km0]] - hHSD + hydroxysteroid<br /> | |||
**[[1fdw]], [[1dht]] - hHSD (mutant) + hydroxysteroid<BR /> | **[[1fdw]], [[1dht]] - hHSD (mutant) + hydroxysteroid<BR /> | ||
**[[ | **[[6mnc]] – hHSD 1 + estrone<br /> | ||
**[[1fdv]] - hHSD (mutant) + NAD<BR /> | **[[1fdv]] - hHSD 1 (mutant) + NAD<BR /> | ||
**[[ | **[[1qyv]] - hHSD 1 + NADP<BR /> | ||
**[[ | **[[1i5r]], [[6dtp]] - hHSD 1 + inhibitor<br /> | ||
** | **[[1zbq]] - hHSD 4 + NAD<BR /> | ||
**[[5l7t]], [[5l7w]], [[5l7y]], [[5icm]], [[5en4]] - hHSD 14 + inhibitor<br /> | |||
**[[6h0m]], [[6hno]], [[5js6]], [[5jsf]] - hHSD 14 (mutant) + NAD<br /> | |||
**[[3qwf]] - ClHSD + NADP<BR /> | **[[3qwf]] - ClHSD + NADP<BR /> | ||
**[[4fj0]], [[4fj1]], [[4fj2]], [[4fiz]] – ClHSD + dehydroxy flavonoid inhibitor<br /> | **[[4fj0]], [[4fj1]], [[4fj2]], [[4fiz]] – ClHSD + dehydroxy flavonoid inhibitor<br /> | ||
| Line 124: | Line 132: | ||
**[[1qyw]], [[1qyx]], [[1fdt]] - hHSD 1 + hydroxysteroid + NADP<BR /> | **[[1qyw]], [[1qyx]], [[1fdt]] - hHSD 1 + hydroxysteroid + NADP<BR /> | ||
**[[1a27]], [[1fdu]] - hHSD 1 (mutant) + hydroxysteroid + NADP<BR /> | **[[1a27]], [[1fdu]] - hHSD 1 (mutant) + hydroxysteroid + NADP<BR /> | ||
**[[3hb5]] - hHSD 1 + inhibitor + NADP<BR /> | **[[3hb5]], [[6cge]] - hHSD 1 + inhibitor + NADP<BR /> | ||
**[[4hfr]], [[4hx5]], [[4iju]], [[4ijv]], [[4ijw]], [[4k1l]] - hHSD 1 (mutant) + inhibitor + NADP<br /> | **[[4hfr]], [[4hx5]], [[4iju]], [[4ijv]], [[4ijw]], [[4k1l]], [[6cgc]] - hHSD 1 (mutant) + inhibitor + NADP<br /> | ||
**[[6mne]] – hHSD 1 + NADP + estrone<br /> | |||
**[[5o42]], [[5o43]], [[5o6o]], [[5o6x]], [[5o6z]], [[5o72]] - hHSD 14 + inhibitor + NAD<br /> | **[[5o42]], [[5o43]], [[5o6o]], [[5o6x]], [[5o6z]], [[5o72]] - hHSD 14 + inhibitor + NAD<br /> | ||
**[[5hs6]] - hHSD + NAD + estrone<br /> | **[[5hs6]] - hHSD + NAD + estrone<br /> | ||
**[[4cql]] - hHSD 8 + carbonyl reductase + NAD<br /> | **[[4cql]] - hHSD 8 + carbonyl reductase + NAD<br /> | ||
**[[4cqm]] - hHSD 8 + carbonyl reductase + NADP<br /> | **[[4cqm]] - hHSD 8 + carbonyl reductase + NADP<br /> | ||
**[[5o42]], [[5o43]], [[5o6o]], [[5o6x]], [[5o6z]], [[5o72]] - hHSD 14 + inhibitor + NAD<br /> | |||
**[[6ffb]], [[6g4l]], [[6gtu]], [[5o7c]] - hHSD 14 (mutant) + inhibitor + NAD<br /> | |||
**[[6emm]] - hHSD 14 (mutant) + salicilate + NAD<br /> | |||
**[[5hs6]] - hHSD 14 + NAD + estrone<br /> | |||
**[[3qwi]], [[3qwh]] - ClHSD + hydroxysteroid + NADP<BR /> | **[[3qwi]], [[3qwh]] - ClHSD + hydroxysteroid + NADP<BR /> | ||
