Insertase

spinqualitylabelsall models Cryo EM structure of E. coli insertase (cyan) complex with membrane domain of ATP synthase (green) PDB code 4utq. Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Insertase (Ins) catalyzes the insertion of proteins into the prokaryotic plasma membrane. Ins interacts with its substrate in a groove-like structure at an ampiphilic protein-lipid interface allowing the transmembrane segments of the substrate to slide into the lipid bilayer. Structural highlights E. Coli Ins (YidC) contains 6 transmembrane segments. Two of these segments was found to interact with a helical segments of a protein which is a candidate for insertion into a plasma membrane.

3D structures of insertase

Updated on 29-August-2019

5m5h, 3wvf - EcIns YidC - Escherichia coli - Cryo EM
6al2 - EcIns YidC
3bs6 - EcIns YidC periplasmic domain
4utq - EcIns YidC + ATP synthase subunit C - Cryo EM
5mg3 - EcIns YidC + SECY + SECE + SECG + SECD + SECF - Cryo EM
3wo7, 3wo6 - Ins YidC - Bacillus halodurans
4c4v - EcIns BamA reasidues 344-808
5ekq - Ins BamA + BamC + BamD + BamE
4k3b - Ins BamA - Neisseria gonorrhoeae
4k3c - Ins BamA - Haemophilus Ducreyi
5y82, 5y83 - Ins YidC (mutant) - Thermotoga maritima

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Michal Harel, Alexander Berchansky