RNase P: Difference between revisions

Revision as of 18:51, 2 September 2019

Updated on 02-September-2019

Cryo-electron microscopy structure of an archaeal ribonuclease P holoenzyme.

Structural insights into protein-only RNase P complexed with tRNA

transfer RNAs - RNP-based RNase P - S. cerevisiae
6ah3 - RNP-based RNase P bound to pre-tRNA - S. cerevisiae

1jox 1jp0 1u9s

2a2e 2k3r 2ki7 2vrt

3iab 3q1q 3q1r

4g23 4g24 4g25 4g26 4xgl

4xgm

5diz 5xtm

6ahv 6bv5 6bv6 6bv8 6bv9

@@ Line 1: / Line 1: @@
 <StructureSection load='6ah3' size='350' side='right' caption=Yeast RNase P bound to pre-tRNA (PDB entry [[6ah3]])' scene=''>
 == Function ==
-''RNase P'' processing the 5′ end of pre-[[Transfer RNA (tRNA)|transfer RNAs]] as well as other RNA molecules.<ref>PMID:28697848</ref>. Most RNase Ps are complexes of proteins and RNAs, termed ribonucleoprotein complexes; however, a few protein-only RNase Ps have been described.<ref>PMID:23322041</ref>
+'''RNase P''' processing the 5′ end of pre-[[Transfer RNA (tRNA)|transfer RNAs]] as well as other RNA molecules.<ref>PMID:28697848</ref>. Most RNase Ps are complexes of proteins and RNAs, termed ribonucleoprotein complexes; however, a few protein-only RNase Ps have been described.<ref>PMID:23322041</ref>
 In eukaryotes, the RNase P proteins have been found to have other roles. For example, many of the proteins are shared with a related RNase P, the small nucleolar RNase MRP, that is involved in processing ribosomal RNA.<ref>PMID:19395864</ref> In yeast, the proteins of RNase P also bind telomerase.<ref>PMID:27156450</ref>