Symporter

spinqualitylabelsall models Dipeptide: H+ symporter (green) complex with dipeptide (cyan), lipid and phosphate (PDB code 4d2c) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Symporter (Symp) is a co-transporter membrane protein which transports two or more different molecules across the plasma membrane in the same direction. Disease Mutations in sodium/iodide symporter cause iodide transport defects. Structural highlights Dipeptide: H symporter binds the dipeptide between its N- and C-terminal bundles.

3D Structures of symporter

Updated on 16-September-2019

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• D-xylose/H+ symporter
  • 4ja4, 4qiq – EcSymp – Escherichia coli
    
  • 4ja3 – EcSymp (mutant)
    
  • 4gby – EcSymp + xylose
    
  • 4gbz, 4gc0 – EcSymp + glucose derivative
    
• Di-or tripeptide/H+ symporter
  • 4ja4, 4xni, 4xnj, 4d2b, 4aps, 5d6k, 5mmt, 5d6k, 5oxo, 5oxp, 5oxq, 6eia, 6fmr, 6fmy – StSymp – Streptococcus thermophilus
    
  • 4d2d, 6ghj – StSymp + tripeptide
    
  • 4d2c, 5d58, 5d59, 5oxk, 5oxl, 5oxm, 5oxn – StSymp + dipeptide
    
• Oligopeptide/H+ symporter
  • 4lep, 4tph – SoSymp – Shewanella oneidensis
    
  • 2xut – SoSymp (mutant)
    
  • 4tpg, 4tpj – SoSymp + tripeptide
    
• Bile acid/Na+ symporter
  • 4n7w – YfSymp – Yersinia frederiksenii
    
  • 4n7x – YfSymp (mutant)
    
  • 3zuy – Symp - Neisseria meningitidis
    
  • 3zux – Symp (mutant)
    
• L-fucose/H+ symporter
  • 3o7q – EcSymp
    
  • 3o7p – EcSymp (mutant)
    
• Lactose/H+ symporter
  • 1pv6 – EcSymp (mutant)
    
  • 1pv7, 4oaa – EcSymp (mutant) + thiodigalactoside
    
• Glucose/Na+ symporter
  • 2xq2 – VpSymp (mutant) – Vibrio parahaemolyticus
    
  • 3dh4 – VpSymp + galactose
    
  • 4m64 – Symp (mutant) - Salmonella typhimurium
    
• Citrate/Na+ symporter
  • 5a1s – Symp + citrate + Na – Salmonella enterica
    
  • 5x9r, 5xas, 5xat – KpSymp + citrate + Na – Klebsiella pneumoniae
    
  • 4bpq, 5xar – KpSymp
    
• Neurotransmitter/leucine symporter LeuT
  • 5jaf, 5jae – AaSymp - Aquifex aeolicus
    
  • 5jag – AaSymp (mutant)
    
  • 3gjd – AaSymp + Na
    
  • 3f48 – AaSymp + alaine + Na
    
  • 3tu0 – AaSymp (mutant) + alanine + Na
    
  • 3f4j – AaSymp + glycine + Na
    
  • 2a65, 3f3e, 3usg, 3usi, 3usj, 3usk – AaSymp + leucine + Na
    
  • 3mpn, 3mpq, 3gjc, 4hmk, 4hod, 4fxz – AaSymp (mutant) + leucine + Na
    
  • 3f3a – AaSymp + tryptophan + Na
    
  • 3qs4, 3qs5, 3qs6 – AaSymp (mutant) + tryptophan + Na
    
  • 3f3c – AaSymp + phenylalanine + Na
    
  • 3f3d, 3f4i, 3usl, 3usm, 3uso – AaSymp + methionine derivative + Na
    
  • 4fy0 – AaSymp (mutant) + methionine + Na
    
  • 2qei – AaSymp + alaine + clomipramine + Na
    
  • 3gwu – AaSymp + sertraline + Na
    
  • 3gwv, 3gww, 2qb4, 2q6h, 2q72, 2qju – AaSymp + drug + Na
    
  • 4mm4 – AaSymp (mutant) + drug + Na
    
  • 3usp – AaSymp + glucoside derivative + Na
    
  • 3tt1, 3tt3 – AaSymp (mutant) + antibody + Na
    
• Divalent ion/Na+ symporter
  • 5ul7, 5ul9, 5uld, 5ule, 4f35 – Symp + Na – Vibrio cholerae
    
• Purine/H+ symporter
  • 5i6c – Symp + xanthine – Aspergillus nidulans
    
• Glutamate/H+ symporter
  • 5dwy, 4ky0 – TkSymp – Thermococcus kodakarensis
    
  • 5e9s – TkSymp + aspartate
    
  • 4oyf – PhSymp - Pyrococcus horikishii
    
  • 2nwl – PhSymp (mutant) + aspartate
    

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