Mu Opioid Receptor: Difference between revisions

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In the presence of a signaling molecule, an active G protein will have GTP bound, to promote an intracellular signaling cascade. After the G protein has transduced the signal, it exchanges GTP for GDP and becomes inactive until another signaling molecule binds to the GPCR.

In the case of the μ-opioid receptor, the binding of an opioid signaling molecule induces a conformational change in the receptor that activates an inhibitory G-protein (Gαi/o). This results in the dissociation of the G-protein complex. The Gα subunit then inhibits adenylyl cyclase. The Gβγ subunit acts to inhibit Ca2+ channels while activing K+ channels. While much has been learned about μ-opioid receptors since their discovery in 1973, there is still much that is unknown about their structure and activation mechanism. Thus, further research into this area is needed. <ref>DOI: 10.1016/j.str.2011.08.003</ref>

In the case of the μ-opioid receptor, the binding of an opioid signaling molecule induces a <scene name='78/786661/Mor_on_off/1'>conformational change</scene> in the receptor that activates an inhibitory G-protein (Gαi/o). This results in the dissociation of the G-protein complex. The Gα subunit then inhibits adenylyl cyclase. The Gβγ subunit acts to inhibit Ca2+ channels while activing K+ channels. While much has been learned about μ-opioid receptors since their discovery in 1973, there is still much that is unknown about their structure and activation mechanism. Thus, further research into this area is needed. <ref>DOI: 10.1016/j.str.2011.08.003</ref>

== Disease ==

Mu Opioid Receptor: Difference between revisions

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@@ Line 13: / Line 13: @@
 In the presence of a signaling molecule, an active G protein will have GTP bound, to promote an intracellular signaling cascade.  After the G protein has transduced the signal, it exchanges GTP for GDP and becomes inactive until another signaling molecule binds to the GPCR.
-In the case of the μ-opioid receptor, the binding of an opioid signaling molecule induces a conformational change in the receptor that activates an inhibitory G-protein (Gαi/o).  This results in the dissociation of the G-protein complex.  The Gα subunit then inhibits adenylyl cyclase.  The Gβγ subunit acts to inhibit Ca2+ channels while activing K+ channels.  While much has been learned about μ-opioid receptors since their discovery in 1973, there is still much that is unknown about their structure and activation mechanism.  Thus, further research into this area is needed. <ref>DOI: 10.1016/j.str.2011.08.003</ref>
+In the case of the μ-opioid receptor, the binding of an opioid signaling molecule induces a <scene name='78/786661/Mor_on_off/1'>conformational change</scene> in the receptor that activates an inhibitory G-protein (Gαi/o).  This results in the dissociation of the G-protein complex.  The Gα subunit then inhibits adenylyl cyclase.  The Gβγ subunit acts to inhibit Ca2+ channels while activing K+ channels.  While much has been learned about μ-opioid receptors since their discovery in 1973, there is still much that is unknown about their structure and activation mechanism.  Thus, further research into this area is needed. <ref>DOI: 10.1016/j.str.2011.08.003</ref>
 == Disease ==