Sandbox GGC9: Difference between revisions
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== ligands == | == ligands == | ||
The ligands that have a high affinity to the AR are Testosterone (T) and Dihydrotestosterone (DHT). Testosterone is a cholesterol derivative, this hormone helps facilitate male maturation and development. Dihydrotestosterone is a tissue metabolite of testosterone and is significantly more potent then testosterone. | The ligands that have a high affinity to the AR are Testosterone (T) and Dihydrotestosterone (DHT). Testosterone is a cholesterol derivative, this hormone helps facilitate male maturation and development. Dihydrotestosterone is a tissue metabolite of testosterone and is significantly more potent then testosterone. <scene name='75/752271/1_ligand/1'>Testosterone Ball and stick</scene> | ||
==binding pocket== | ==binding pocket== | ||
The way AR binds the dozens of coregulator proteins reported to associate with different regions of AR are poorly understood. Nuclear receptors activate transcription by binding short sequences such as LxxLL or FXXLF (where “x” is any amino acid). these residues bid to the OH group on the testosterone and allow for pocket stabilization.<scene name='75/752271/1_ar_b_pocket_alpha_c_labeled/3'>Androgen receptor binding pocket W/O ligand</scene> | The way AR binds the dozens of coregulator proteins reported to associate with different regions of AR are poorly understood. Nuclear receptors activate transcription by binding short sequences such as LxxLL or FXXLF (where “x” is any amino acid). these residues bid to the OH group on the testosterone and allow for pocket stabilization.<scene name='75/752271/1_ar_b_pocket_alpha_c_labeled/3'>Androgen receptor binding pocket W/O ligand</scene> | ||
