RNA Polymerase II: Difference between revisions
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== Introduction == | == Introduction == | ||
RNA polymerase II (RNAP II) is an enzyme that transcribes protein-encoding genes, therefore it is responsible for the synthesis of mRNA. | RNA polymerase II (RNAP II) is an enzyme that transcribes protein-encoding genes, therefore it is responsible for the synthesis of mRNA.Brief description of mRNA | ||
== Structural Components == | == Structural Components == | ||
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4. <scene name='82/824648/Tfiie/1'>TFIIE</scene> and <scene name='82/824648/Tfiih/1'>TFIIH</scene> are sequentually recruited which completes the PIC. | 4. <scene name='82/824648/Tfiie/1'>TFIIE</scene> and <scene name='82/824648/Tfiih/1'>TFIIH</scene> are sequentually recruited which completes the PIC. | ||
PIC NON-TRANSPARENT COMPLEX | |||
FIGURE CAPTIONS-PDB AND COLOR | |||
CENTERING F | |||
Once the PIC is formed, RNAP II initiates RNA synthesis and produces a short transcript. When RNAP II becomes phosphorylated, it releases some of the GTFs from the complex and moves away from the promoter. TFIID stays bound to the promoter and can reinitiate transcription. The transcription factors are replaced by a new six-protein complex call the Elongator. TFIIF and TFIIH both remain associated with RNAP II during elongation. | Once the PIC is formed, RNAP II initiates RNA synthesis and produces a short transcript. When RNAP II becomes phosphorylated, it releases some of the GTFs from the complex and moves away from the promoter. TFIID stays bound to the promoter and can reinitiate transcription. The transcription factors are replaced by a new six-protein complex call the Elongator. TFIIF and TFIIH both remain associated with RNAP II during elongation. | ||
