6gw3: Difference between revisions
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==Structure of TKS from Cannabis sativa in complex with CoA== | |||
<StructureSection load='6gw3' size='340' side='right'caption='[[6gw3]], [[Resolution|resolution]] 1.39Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6gw3]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GW3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GW3 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | |||
[[Category: | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3,5,7-trioxododecanoyl-CoA_synthase 3,5,7-trioxododecanoyl-CoA synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.206 2.3.1.206] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gw3 OCA], [http://pdbe.org/6gw3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gw3 RCSB], [http://www.ebi.ac.uk/pdbsum/6gw3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gw3 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/OLIS_CANSA OLIS_CANSA]] Polyketide synthase responsible for olivetol biosynthesis. Catalyzes the first step in the cannabinoids biosynthetic pathway. The preferred substrate is hexanoyl-CoA, but accepts also CoA esters with C4 to C8 aliphatic side chains. When using malonyl-CoA and hexanoyl-CoA as substrates, produces undetermined compounds distinct form olivetol or olivetolic acid (PubMed:19581347) that could be hexanoyl triacetic acid lactone (HTAL) (PubMed:18323613) and pentyl diacetic acid lactone (PDAL) (PubMed:22802619). Produces olivetolic acid when acting in concert with olivetolic acid cyclase (OAC).<ref>PMID:18323613</ref> <ref>PMID:19454282</ref> <ref>PMID:19581347</ref> <ref>PMID:22802619</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: 3,5,7-trioxododecanoyl-CoA synthase]] | |||
[[Category: Large Structures]] | |||
[[Category: Karuppiah, V]] | |||
[[Category: Leys, D]] | |||
[[Category: 7-trioxododecanoyl-coa synthase]] | |||
[[Category: Ligase]] | |||
[[Category: Pks type iii]] | |||
[[Category: Polyketide synthase]] | |||
Revision as of 05:13, 10 October 2019
Structure of TKS from Cannabis sativa in complex with CoA
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