6mqb: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6mqb is ~~ON HOLD until Oct 09 2020~~

==Crystal Structure of GTPase Domain of Human Septin 12 in complex with GMPPNP in Space Group C2221==

~~Authors~~: ~~Castro, D~~.K.S.V., ~~Pereira, H~~.M.~~, Brandao~~-~~Neto~~, J., ~~Ulian~~, A.P.U., ~~Garratt, R~~.C.

== Structural highlights ==

<table><tr><td colspan='2'>[[6mqb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MQB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MQB FirstGlance]. <br>

~~Description~~: ~~Crystal Structure~~ of ~~GTPase Domain~~ of ~~Human Septin 12 in complex~~ with ~~GMPPNP~~ in ~~Space Group C2221~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mqb OCA], [http://pdbe.org/6mqb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mqb RCSB], [http://www.ebi.ac.uk/pdbsum/6mqb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mqb ProSAT]</span></td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/SEP12_HUMAN SEP12_HUMAN]] Non-syndromic male infertility due to sperm motility disorder. The disease is caused by mutations affecting the gene represented in this entry.

== Function ==

[[http://www.uniprot.org/uniprot/SEP12_HUMAN SEP12_HUMAN]] Filament-forming cytoskeletal GTPase (By similarity). Involved in spermatogenesis. Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating the association with alpha- and beta-tubulins (PubMed:24213608). Forms a filamentous structure with SEPTIN7, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). May play a role in cytokinesis (Potential).<ref>PMID:24213608</ref> <ref>PMID:25588830</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Brandao-Neto, J]]

[[Category: Garratt, R.C]]

[[Category: Castro, D K.S V]]

[[Category: Pereira, H.M]]

[[Category: Garratt, R C]]

[[Category: ~~Castro~~, D.~~K.S.V~~]]

[[Category: Pereira, H M]]

[[Category: ~~Ulian, A.P.U~~]]

[[Category: Ulian, A P.U]]

[[Category: Cytoskeleton component septin gtpase spermatogenesis]]

[[Category: Structural protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6mqb is ON HOLD  until Oct 09 2020
+==Crystal Structure of GTPase Domain of Human Septin 12 in complex with GMPPNP in Space Group C2221==
+<StructureSection load='6mqb' size='340' side='right'caption='[[6mqb]], [[Resolution|resolution]] 2.12&Aring;' scene=''>
-Authors: Castro, D.K.S.V., Pereira, H.M., Brandao-Neto, J., Ulian, A.P.U., Garratt, R.C.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6mqb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MQB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MQB FirstGlance]. <br>
-Description: Crystal Structure of GTPase Domain of Human Septin 12 in complex with GMPPNP in Space Group C2221
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mqb OCA], [http://pdbe.org/6mqb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mqb RCSB], [http://www.ebi.ac.uk/pdbsum/6mqb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mqb ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/SEP12_HUMAN SEP12_HUMAN]] Non-syndromic male infertility due to sperm motility disorder. The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[[http://www.uniprot.org/uniprot/SEP12_HUMAN SEP12_HUMAN]] Filament-forming cytoskeletal GTPase (By similarity). Involved in spermatogenesis. Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating the association with alpha- and beta-tubulins (PubMed:24213608). Forms a filamentous structure with SEPTIN7, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). May play a role in cytokinesis (Potential).<ref>PMID:24213608</ref> <ref>PMID:25588830</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Brandao-Neto, J]]
-[[Category: Garratt, R.C]]
+[[Category: Castro, D K.S V]]
-[[Category: Pereira, H.M]]
+[[Category: Garratt, R C]]
-[[Category: Castro, D.K.S.V]]
+[[Category: Pereira, H M]]
-[[Category: Ulian, A.P.U]]
+[[Category: Ulian, A P.U]]
+[[Category: Cytoskeleton component septin gtpase spermatogenesis]]
+[[Category: Structural protein]]