6r75: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6r75 is ~~ON HOLD~~

==Crystal structure of human Ube2T E54R mutant==

~~Authors~~: ~~Chaugule~~, V.K., ~~Rennie~~, M.L., ~~Walden~~, H.

== Structural highlights ==

<table><tr><td colspan='2'>[[6r75]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R75 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R75 FirstGlance].

~~Description~~: ~~Crystal structure~~ of ~~human Ube2T E54R mutant~~

</td></tr><tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/E2_ubiquitin-conjugating_enzyme E2 ubiquitin-conjugating enzyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.2.23 2.3.2.23] </td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6r75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r75 OCA], [http://pdbe.org/6r75 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r75 RCSB], [http://www.ebi.ac.uk/pdbsum/6r75 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r75 ProSAT]</td></tr>

[[Category: Chaugule, V.K]]

</table>

[[Category: Rennie, M.L]]

== Function ==

[[http://www.uniprot.org/uniprot/UBE2T_HUMAN UBE2T_HUMAN]] Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination.<ref>PMID:16916645</ref> <ref>PMID:17938197</ref> <ref>PMID:19111657</ref> <ref>PMID:19887602</ref> <ref>PMID:19589784</ref> <ref>PMID:20061386</ref>

== References ==

__TOC__

</StructureSection>

[[Category: E2 ubiquitin-conjugating enzyme]]

[[Category: Large Structures]]

[[Category: Arkinson, C]]

[[Category: Chaugule, V K]]

[[Category: Kamarainen, O]]

[[Category: Rennie, M L]]

[[Category: Toth, R]]

[[Category: Walden, H]]

[[Category: Allostery]]

[[Category: Dna repair]]

[[Category: E2]]

[[Category: Ligase]]

[[Category: Ubiquitination]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6r75 is ON HOLD
+==Crystal structure of human Ube2T E54R mutant==
+<StructureSection load='6r75' size='340' side='right'caption='[[6r75]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-Authors: Chaugule, V.K., Rennie, M.L., Walden, H.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6r75]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R75 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R75 FirstGlance]. <br>
-Description: Crystal structure of human Ube2T E54R mutant
+</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/E2_ubiquitin-conjugating_enzyme E2 ubiquitin-conjugating enzyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.2.23 2.3.2.23] </span></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6r75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r75 OCA], [http://pdbe.org/6r75 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r75 RCSB], [http://www.ebi.ac.uk/pdbsum/6r75 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r75 ProSAT]</span></td></tr>
-[[Category: Chaugule, V.K]]
+</table>
-[[Category: Rennie, M.L]]
+== Function ==
+[[http://www.uniprot.org/uniprot/UBE2T_HUMAN UBE2T_HUMAN]] Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination.<ref>PMID:16916645</ref> <ref>PMID:17938197</ref> <ref>PMID:19111657</ref> <ref>PMID:19887602</ref> <ref>PMID:19589784</ref> <ref>PMID:20061386</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: E2 ubiquitin-conjugating enzyme]]
+[[Category: Large Structures]]
+[[Category: Arkinson, C]]
+[[Category: Chaugule, V K]]
+[[Category: Kamarainen, O]]
+[[Category: Rennie, M L]]
+[[Category: Toth, R]]
 [[Category: Walden, H]]
+[[Category: Allostery]]
+[[Category: Dna repair]]
+[[Category: E2]]
+[[Category: Ligase]]
+[[Category: Ubiquitination]]