6ht5: Difference between revisions
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==Oct4/Sox2:UTF1 structure== | |||
<StructureSection load='6ht5' size='340' side='right'caption='[[6ht5]], [[Resolution|resolution]] 3.45Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6ht5]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HT5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HT5 FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ht5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ht5 OCA], [http://pdbe.org/6ht5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ht5 RCSB], [http://www.ebi.ac.uk/pdbsum/6ht5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ht5 ProSAT]</span></td></tr> | |||
[[ | </table> | ||
[[Category: | == Function == | ||
[[http://www.uniprot.org/uniprot/PO5F1_MOUSE PO5F1_MOUSE]] Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.<ref>PMID:17496161</ref> <ref>PMID:17525163</ref> [[http://www.uniprot.org/uniprot/SOX2_MOUSE SOX2_MOUSE]] Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).<ref>PMID:17097055</ref> <ref>PMID:22198669</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Groves, M]] | [[Category: Groves, M]] | ||
[[Category: Meusch, D]] | [[Category: Meusch, D]] | ||
[[Category: Pogenberg, V]] | [[Category: Pogenberg, V]] | ||
[[Category: Vahokoski, J]] | |||
[[Category: Wilmanns, M]] | [[Category: Wilmanns, M]] | ||
[[Category: Cell reprogramming]] | |||
[[Category: Dna binding]] | |||
[[Category: Transcription]] | |||
[[Category: Transcription factor]] | |||
