6sze: Difference between revisions

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'''Unreleased structure'''


The entry 6sze is ON HOLD
==RIP2 Kinase Catalytic Domain complex with 5-Amino-1-Phenylpyrazole-4-Carboxamide.==
 
<StructureSection load='6sze' size='340' side='right'caption='[[6sze]], [[Resolution|resolution]] 2.94&Aring;' scene=''>
Authors: Convery, M.A., Charnley, A.K., Shewchuk, L.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6sze]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SZE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SZE FirstGlance]. <br>
Description: RIP2 Kinase Catalytic Domain complex with 5-Amino-1-Phenylpyrazole-4-Carboxamide.
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=M2B:5-Amino-1-Phenylpyrazole-4-Carboxamide'>M2B</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
[[Category: Charnley, A.K]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6sze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sze OCA], [http://pdbe.org/6sze PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sze RCSB], [http://www.ebi.ac.uk/pdbsum/6sze PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sze ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/RIPK2_HUMAN RIPK2_HUMAN]] Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.<ref>PMID:14638696</ref> <ref>PMID:17054981</ref> <ref>PMID:18079694</ref> <ref>PMID:21123652</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Charnley, A K]]
[[Category: Convery, M A]]
[[Category: Shewchuk, L]]
[[Category: Shewchuk, L]]
[[Category: Convery, M.A]]
[[Category: Receptor interacting protein 2 kinase]]
[[Category: Rip2]]
[[Category: Rip2k]]
[[Category: Ripk2]]
[[Category: Transferase]]
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