6uap: Difference between revisions

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'''Unreleased structure'''


The entry 6uap is ON HOLD
==Crystal structure of tryptophan synthase from M. tuberculosis - open form with BRD6309 bound==
 
<StructureSection load='6uap' size='340' side='right'caption='[[6uap]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
Authors: Chang, C., Michalska, K., Maltseva, N.I., Jedrzejczak, R., McCarren, P., Nag, P.P., Joachimiak, A., Satchell, K., Center for Structural Genomics of Infectious Diseases (CSGID)
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6uap]] is a 8 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=6du1 6du1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UAP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UAP FirstGlance]. <br>
Description: Crystal structure of tryptophan synthase from M. tuberculosis -open form with BRD6309 bound
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=H9V:(2R,3S,4R)-3-(4-chloro-2,6-difluoro[1,1-biphenyl]-4-yl)-4-(fluoromethyl)azetidine-2-carbonitrile'>H9V</scene>, <scene name='pdbligand=MLA:MALONIC+ACID'>MLA</scene>, <scene name='pdbligand=MLT:D-MALATE'>MLT</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptophan_synthase Tryptophan synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.20 4.2.1.20] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6uap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uap OCA], [http://pdbe.org/6uap PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6uap RCSB], [http://www.ebi.ac.uk/pdbsum/6uap PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6uap ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/TRPA_MYCTU TRPA_MYCTU]] The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. [[http://www.uniprot.org/uniprot/TRPB_MYCTU TRPB_MYCTU]] The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine (By similarity).
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Tryptophan synthase]]
[[Category: Structural genomic]]
[[Category: Chang, C]]
[[Category: Jedrzejczak, R]]
[[Category: Joachimiak, A]]
[[Category: Maltseva, N I]]
[[Category: McCarren, P]]
[[Category: Michalska, K]]
[[Category: Michalska, K]]
[[Category: Mccarren, P]]
[[Category: Nag, P P]]
[[Category: Joachimiak, A]]
[[Category: Maltseva, N.I]]
[[Category: Satchell, K]]
[[Category: Satchell, K]]
[[Category: Jedrzejczak, R]]
[[Category: Allostery]]
[[Category: Center For Structural Genomics Of Infectious Diseases (Csgid)]]
[[Category: Amino acid biosynthesis]]
[[Category: Chang, C]]
[[Category: Csgid]]
[[Category: Nag, P.P]]
[[Category: Heterotetramer]]
[[Category: Lyase-lyase inhibitor complex]]
[[Category: Plp]]
[[Category: Substrate channeling]]
Retrieved from "https://proteopedia.org/6uap"