6in3: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Crystal structure of DOT1L in complex with 18-Crown-6== | |||
<StructureSection load='6in3' size='340' side='right'caption='[[6in3]], [[Resolution|resolution]] 2.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6in3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IN3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IN3 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=O4B:1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE'>O4B</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6in3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6in3 OCA], [http://pdbe.org/6in3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6in3 RCSB], [http://www.ebi.ac.uk/pdbsum/6in3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6in3 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/DOT1L_HUMAN DOT1L_HUMAN]] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Histone-lysine N-methyltransferase]] | |||
[[Category: Large Structures]] | |||
[[Category: Kitakami, R]] | |||
[[Category: Kosaka, Y]] | |||
[[Category: Matsumoto, K]] | |||
[[Category: Mizuguchi, M]] | |||
[[Category: Nabeshima, Y]] | |||
[[Category: Yokoyama, T]] | |||
[[Category: Histone h3k79 methyltransferase]] | |||
[[Category: Transferase]] | |||
Revision as of 08:59, 30 October 2019
Crystal structure of DOT1L in complex with 18-Crown-6
| ||||||||||||
