Myosin: Difference between revisions

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==Disease==
==Disease==
Mutations in MIIA cause early onset myopathy<ref>PMID:20418530</ref>.  Mutations in MVIIA cause Usher syndrome<ref>PMID:7870171</ref>.
Mutations in MIIA cause early onset myopathy<ref>PMID:20418530</ref>.  Mutations in MVIIA cause Usher syndrome<ref>PMID:7870171</ref>.
== 3D Structures of Myosin ==
[[Myosin 3D Structures]]
</StructureSection>
</StructureSection>


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* Myosin I  
* Myosin I  


**[[4byf]] – hMIC + calmodulin – human<br />
**[[2xmf]] – mMI SH3 domain - mouse<br />
**[[5h53]] - rMI LC+HC + rActin – rabbit - Cryo EM<br />
**[[1lkx]], [[5ejy]] – DdMI HC - ''Dictyostelium discoideum''<br />
**[[1lkx]], [[5ejy]] – DdMI HC - ''Dictyostelium discoideum''<br />
**[[5ejs]] – DdMI HC (mutant)<br />
**[[5ejs]] – DdMI HC (mutant)<br />
**[[4a7f]] - DdMI HC + rActin + rTropomyosin – rabbit – Cryo EM<br />
**[[4a7f]] - DdMI HC + rActin + rTropomyosin – Cryo EM<br />
**[[4a7h]], [[4a7l]] - DdMI HC (mutant) + rActin + rTropomyosin – Cryo EM<br />
**[[4a7h]], [[4a7l]] - DdMI HC (mutant) + rActin + rTropomyosin – Cryo EM<br />
**[[5ibw]] – DdMIC HC + Ca-binding protein <br />
**[[5ibw]] – DdMIC HC + Ca-binding protein <br />
**[[2drk]], [[2drm]] – MI HC + 10-mer peptide – ''Acanthamoeba castellanii''<br />
**[[2drk]], [[2drm]] – MI HC + 10-mer peptide – ''Acanthamoeba castellanii''<br />
**[[2xmf]] – mMI SH3 domain - mouse<br />
**[[6i7e]], [[6i7d]] – MI – ''Plasmodium falciparum''<br />
**[[4byf]] – hMIC + calmodulin – human<br />
**[[5h53]] - rMI LC+HC + rActin – Cryo EM<br />


*Unconventional myosin I
*Unconventional myosin I
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**[[4l79]] – raMIB + calmodulin <br />
**[[4l79]] – raMIB + calmodulin <br />
**[[6c1d]] – raMIB + calmodulin + actin + phalloidin – Cryo EM<br />
**[[6c1d]] – raMIB + calmodulin + actin + phalloidin – Cryo EM<br />
**[[5xgg]], [[5xg9]] – MIB C-terminal SH3 – ''Entamoeba histolytica''<br />
**[[4r8g]] – mMIC C-terminal + calmodulin<br />
**[[4r8g]] – mMIC C-terminal + calmodulin<br />
**[[5xgg]], [[5xg9]] – EhMIB C-terminal SH3 – ''Entamoeba histolytica''<br />
**[[6a9c]] – EhMIB C-terminal SH3 + FP10 peptide<br />


* Myosin II  
* Myosin II  
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**[[2aka]] - DdMII HC+dynamin-1<br />
**[[2aka]] - DdMII HC+dynamin-1<br />
**[[2xel]], [[4ae3]] – DdMII HC + inhibitor<br />
**[[2xel]], [[4ae3]] – DdMII HC + inhibitor<br />
**[[1n2d]] – ScMII LC+IQ2 IQ3 motifs from Myo2p<br />
**[[6ixo]] – yMII GTD - yeast<br />
**[[1m45]] - ScMII LC+IQ2 motif from Myo2p<br />
**[[1n2d]] – yMII LC+IQ2 IQ3 motifs from Myo2p<br />
**[[1m46]] - ScMII LC+IQ4 motif from Myo2p<br />
**[[1m45]] - yMII LC+IQ2 motif from Myo2p<br />
**[[1m46]] - yMII LC+IQ4 motif from Myo2p<br />
**[[6ixr]], [[6ixq]], [[6ixp]] – yMII GTD (mutant) + peptide<br />
**[[2bl0]] – MII RLC +RHC – ''Physarum polycephalum''<br />
**[[2bl0]] – MII RLC +RHC – ''Physarum polycephalum''<br />
**[[5w1a]] - MII HC MD + LC – ''Drosophila melanogaster''<br />
**[[5w1a]] - MII HC MD + LC – ''Drosophila melanogaster''<br />
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*Myosin IV
*Myosin IV


**[[3mmi]] – yMIV globular tail <br />
**[[3mmi]] – yMIV GTD <br />
**[[4ll6]] - yMIV globular tail (mutant)<br />
**[[4ll6]] - yMIV GTD (mutant)<br />
**[[4ll8]] - yMIV globular tail (mutant) + SHE3P<br />
**[[4ll8]] - yMIV GTD (mutant) + SHE3P<br />
**[[6qdj]] – MIV – ''Caenorhabditis elegans'' <br />
 
*Myosin V
 
**[[6eyw]] - yMV CBD<br />


* Myosin V (Unconventional myosin)
* Myosin V (Unconventional myosin)
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**[[4zlk]] - mMVA + calmodulin<br />
**[[4zlk]] - mMVA + calmodulin<br />
**[[2ix7]] – mMVA IQ motif +apo-calmodulin <br />
**[[2ix7]] – mMVA IQ motif +apo-calmodulin <br />
**[[3wb8]] – mMVA tail domain<br />
**[[3wb8]] – mMVA GTD<br />
**[[4j5l]], [[4j5m]] – hMVA tail domain<br />
**[[4j5l]], [[4j5m]] – hMVA GTD<br />
**[[4kp3]] – mMVA tail domain + RILP-like protein + melanophilin<br />
**[[4kp3]] – mMVA GTD + RILP-like protein + melanophilin<br />
**[[4lli]] – hMVA cargo binding domain<br />
**[[4lli]] – hMVA CBD<br />
**[[4lx1]] – hMVA globular tail domain<br />
**[[4lx1]] – hMVA GTD<br />
**[[4lx2]] – hMVA globular tail domain + melanphilin<br />
**[[4lx2]] – hMVA GTD + melanphilin<br />
**[[5jcz]] – hMVA globular tail domain + RAB-11<br />
**[[5jcz]] – hMVA GTD + RAB-11<br />
**[[5jcy]] – hMVA globular tail domain + SPIR-2<br />
**[[5jcy]] – hMVA GTD + SPIR-2<br />
**[[4lnz]] – hMVB globular domain<br />
**[[4lnz]] – hMVB GTD<br />
**[[4lwz]], [[4lx0]] – hMVB globular tail + RAS-related protein<br />
**[[4lwz]], [[4lx0]] – hMVB GTD + RAS-related protein<br />
**[[5hmp]], [[4zg4]] – hMVC <br />
**[[5hmp]], [[4zg4]] – hMVC <br />
**[[4l8t]] – hMVC cargo binding domain<br />
**[[4l8t]] – hMVC CBD<br />


* Myosin VI  
* Myosin VI  
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**[[6bnw]], [[6bnq]], [[6bnp]] – pMVI + actin – Cryo EM<br />
**[[6bnw]], [[6bnq]], [[6bnp]] – pMVI + actin – Cryo EM<br />
**[[6bnv]] – pMVI + actin + calmodulin – Cryo EM<br />
**[[6bnv]] – pMVI + actin + calmodulin – Cryo EM<br />
**[[6bnv]] – MVI residus 1-69 – ''Meriones unguiculatus''<br />


*Unconventional myosin VI
*Unconventional myosin VI


**[[6j56]] – hMVI CBD + TOM1 peptide  <br />
**[[5v6h]] – mMVI + GIPC2  <br />
**[[5v6h]] – mMVI + GIPC2  <br />
**[[5v6e]] – mMVI + GIPC1  <br />
**[[5v6e]] – mMVI + GIPC1  <br />
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**[[5c5s]] – hMIXB RHOGAP domain  <br />
**[[5c5s]] – hMIXB RHOGAP domain  <br />
**[[5hpy]] – hMIXB motor domain + RHOA  <br />
**[[5hpy]] – hMIXB MD + RHOA  <br />


*Myosin X
*Myosin X
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*Unconventional myosin X
*Unconventional myosin X


**[[5i0h]] – hMX motor domain <br />
**[[5i0h]] – hMX MD <br />
**[[5kg8]] – hMX motor domain + actin <br />
**[[5kg8]] – hMX MD + actin <br />
**[[5i0i]] – hMX motor domain + calmodulin <br />
**[[5i0i]] – hMX MD + calmodulin <br />
**[[5hmo]] – MX SAH + coiled-coil domain - bovine <br />
**[[5hmo]] – MX SAH + coiled-coil domain - bovine <br />


*Myosin XI
*Myosin XI


**[[5t45]] – cMXI motor domain <br />
**[[5t45]] – cMXI MD <br />
**[[5m05]] – cMXI motor domain + inhibitor <br />
**[[5m05]] – cMXI MD + inhibitor <br />
**[[3j04]] – cMXI HC + RLC – Cryo EM
**[[3j04]] – cMXI HC + RLC – Cryo EM<br />
**[[6bih]] – cMXI HC + actin – Cryo EM<br />
 
*Unconventional myosin XIV
 
**[[6due]] – MXIV – ''Toxoplasma gondii''  <br />


*Flight muscle myosin
*Flight muscle myosin

Revision as of 10:07, 5 November 2019

Squid myosin II: heavy chain (grey), regulatory light chain (green), catalytic light chain (pink) complex with ADP and Mg+2 ion (green) 3i5f

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3D Structures of Myosin

Updated on 05-November-2019

References

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