6qb4: Difference between revisions
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==Mcl1-scFv complex with an indole acid inhibitor== | |||
<StructureSection load='6qb4' size='340' side='right'caption='[[6qb4]], [[Resolution|resolution]] 2.38Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6qb4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QB4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QB4 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HVN:3-[3-[[(1~{R})-1,2,3,4-tetrahydronaphthalen-1-yl]oxy]propyl]-7-(1,3,5-trimethylpyrazol-4-yl)-1~{H}-indole-2-carboxylic+acid'>HVN</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6qb3|6qb3]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qb4 OCA], [http://pdbe.org/6qb4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qb4 RCSB], [http://www.ebi.ac.uk/pdbsum/6qb4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qb4 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Hargreaves, D]] | [[Category: Hargreaves, D]] | ||
[[Category: Apoptosis]] | |||
[[Category: Indole acid]] | |||
[[Category: Mcl1]] | |||
[[Category: Scfv]] | |||
Revision as of 06:47, 6 November 2019
Mcl1-scFv complex with an indole acid inhibitor
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