6t1m: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6t1m ~~is ON HOLD~~

==Crystal structure of MLLT1 (ENL) YEATS domain in complexed with benzimidazole-amide derivative 4==

~~Authors~~: ~~Chaikuad, A~~., ~~Heidenreich~~, D., ~~Moustakim~~, M., ~~Arrowsmith, C~~.H., ~~Edwards, A~~.M., ~~Bountra, C~~.~~, Fedorov, O~~.~~, Brennan, P~~.E.~~, Knapp, S~~.~~, Structural Genomics Consortium~~ (~~SGC~~)

== Structural highlights ==

<table><tr><td colspan='2'>[[6t1m]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T1M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6T1M FirstGlance]. <br>

~~Description~~: ~~Crystal structure~~ of ~~MLLT1~~ (~~ENL~~) ~~YEATS domain in complexed with benzimidazole-amide derivative 4~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=M8K:4-cyano-~{N}-[2-(piperidin-1-ylmethyl)-1~{H}-benzimidazol-5-yl]benzamide'>M8K</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6t1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t1m OCA], [http://pdbe.org/6t1m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6t1m RCSB], [http://www.ebi.ac.uk/pdbsum/6t1m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6t1m ProSAT]</span></td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/ENL_HUMAN ENL_HUMAN]] A chromosomal aberration involving MLLT1 is associated with acute leukemias. Translocation t(11;19)(q23;p13.3) with KMT2A/MLL1. The result is a rogue activator protein.

== Function ==

[[http://www.uniprot.org/uniprot/ENL_HUMAN ENL_HUMAN]] Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.<ref>PMID:20159561</ref> <ref>PMID:20471948</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Arrowsmith, C H]]

[[Category: Bountra, C]]

[[Category: Brennan, P E]]

[[Category: Chaikuad, A]]

[[Category: Edwards, A M]]

[[Category: Fedorov, O]]

[[Category: Heidenreich, D]]

[[Category: Knapp, S]]

~~[[Category: Edwards, A.M]]~~

~~[[Category: Arrowsmith, C.H]]~~

~~[[Category: Brennan, P.E]]~~

~~[[Category: Fedorov, O]]~~

~~[[Category: Structural Genomics Consortium (Sgc)]]~~

~~[[Category: Bountra, C]]~~

[[Category: Moustakim, M]]

[[Category: Structural genomic]]

[[Category: Chemical probe]]

[[Category: Enl]]

[[Category: Inhibitor]]

[[Category: Mllt1]]

[[Category: Sgc]]

[[Category: Transcription]]

[[Category: Yeats domain]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6t1m is ON HOLD
+==Crystal structure of MLLT1 (ENL) YEATS domain in complexed with benzimidazole-amide derivative 4==
+<StructureSection load='6t1m' size='340' side='right'caption='[[6t1m]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
-Authors: Chaikuad, A., Heidenreich, D., Moustakim, M., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Fedorov, O., Brennan, P.E., Knapp, S., Structural Genomics Consortium (SGC)
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6t1m]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T1M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6T1M FirstGlance]. <br>
-Description: Crystal structure of MLLT1 (ENL) YEATS domain in complexed with benzimidazole-amide derivative 4
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=M8K:4-cyano-~{N}-[2-(piperidin-1-ylmethyl)-1~{H}-benzimidazol-5-yl]benzamide'>M8K</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6t1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t1m OCA], [http://pdbe.org/6t1m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6t1m RCSB], [http://www.ebi.ac.uk/pdbsum/6t1m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6t1m ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/ENL_HUMAN ENL_HUMAN]] A chromosomal aberration involving MLLT1 is associated with acute leukemias. Translocation t(11;19)(q23;p13.3) with KMT2A/MLL1. The result is a rogue activator protein.
+== Function ==
+[[http://www.uniprot.org/uniprot/ENL_HUMAN ENL_HUMAN]] Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.<ref>PMID:20159561</ref> <ref>PMID:20471948</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Arrowsmith, C H]]
+[[Category: Bountra, C]]
+[[Category: Brennan, P E]]
 [[Category: Chaikuad, A]]
+[[Category: Edwards, A M]]
+[[Category: Fedorov, O]]
 [[Category: Heidenreich, D]]
 [[Category: Knapp, S]]
-[[Category: Edwards, A.M]]
-[[Category: Arrowsmith, C.H]]
-[[Category: Brennan, P.E]]
-[[Category: Fedorov, O]]
-[[Category: Structural Genomics Consortium (Sgc)]]
-[[Category: Bountra, C]]
 [[Category: Moustakim, M]]
+[[Category: Structural genomic]]
+[[Category: Chemical probe]]
+[[Category: Enl]]
+[[Category: Inhibitor]]
+[[Category: Mllt1]]
+[[Category: Sgc]]
+[[Category: Transcription]]
+[[Category: Yeats domain]]