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| **[[4rn5]] – hNRP-1 B1 domain<br /> | | **[[4rn5]] – hNRP-1 B1 domain<br /> |
| **[[5l73]] – hNRP-1 MAM domain<br /> | | **[[5l73]] – hNRP-1 MAM domain<br /> |
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| **[[2qqm]] - hNRP-1 A2+B1+B2 domains<br /> | | **[[2qqm]] - hNRP-1 A2+B1+B2 domains<br /> |
| **[[4deq]] - hNRP-1 B1 domain + VEGF-A heparin-binding domain<br /> | | **[[4deq]] - hNRP-1 B1 domain + VEGF-A heparin-binding domain<br /> |
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| **[[5c7g]] – hNRP-1 B1 domain + bicine<br /> | | **[[5c7g]] – hNRP-1 B1 domain + bicine<br /> |
| **[[5ijr]], [[5iyy]], [[5j1x]], [[5jgi]], [[5jgq]], [[5jhk]] – hNRP-1 B1 domain + arginine derivative<br /> | | **[[5ijr]], [[5iyy]], [[5j1x]], [[5jgi]], [[5jgq]], [[5jhk]] – hNRP-1 B1 domain + arginine derivative<br /> |
| **[[3i97]] - hNRP-1 B1 domains + inhibitor | | **[[3i97]], [[6fmc]], [[6fmf]] - hNRP-1 B1 domains + inhibitor |
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| **[[2orx]] – rNRP-1 B domains – rat | | **[[2orx]] – rNRP-1 B domains – rat |
Revision as of 08:40, 7 November 2019
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Function
Neuropilin (NRP) are neuronal receptors. NRP are co-receptors for semaphorins[1]. There are 2 classes of NRP – NRP-1 and NRP-2.
- NRP-1 has high affinity for semaphorin-3A.
- NRP-2 has high affinity for semaphorin-3F.
Relevance
NRP are highly expressed in human neoplasms[2].
Structural highlights
NPR structure contains the extracellular domains A1, A2 which bind semaphorin; B1, B2 which bind VEGF and C which is the dimerization region.
- ↑ Romeo PH, Lemarchandel V, Tordjman R. Neuropilin-1 in the immune system. Adv Exp Med Biol. 2002;515:49-54. PMID:12613542
- ↑ Pellet-Many C, Frankel P, Jia H, Zachary I. Neuropilins: structure, function and role in disease. Biochem J. 2008 Apr 15;411(2):211-26. doi: 10.1042/BJ20071639. PMID:18363553 doi:https://dx.doi.org/10.1042/BJ20071639
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3D Structures of Neuropilin
Updated on 07-November-2019
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- NRP-1
- 1kex, 2qqi – hNRP-1 B1 domain – human
- 4rn5 – hNRP-1 B1 domain
- 5l73 – hNRP-1 MAM domain
- 2qqm - hNRP-1 A2+B1+B2 domains
- 4deq - hNRP-1 B1 domain + VEGF-A heparin-binding domain
- 2qqn - hNRP-1 B1 domain + VEGF-blocking antibody
- 5c7g – hNRP-1 B1 domain + bicine
- 5ijr, 5iyy, 5j1x, 5jgi, 5jgq, 5jhk – hNRP-1 B1 domain + arginine derivative
- 3i97, 6fmc, 6fmf - hNRP-1 B1 domains + inhibitor
- 2orx – rNRP-1 B domains – rat
- 2orz – rNRP-1 B domains + tuftsin peptide
- 4gz9 - mNRP-1 A1+A2+B1+B2 domain – mouse
- 4gza - mNRP-1 A1+A2+B1+B2 domains + plexin A2 + semaphorin 3A
- NRP-2; Domains - CUB 27-145; A2 145-275; B1 275-430; B2 431-595
- 4qdq, 4qds, 2qqj - hNRP-2 B1+B2 domains
- 5dq0 – hNRP-2 B1 domain
- 4qdr - hNRP-2 B1+B2 domain (mutant)
- 2qqo - hNRP-2 A2+B1+B2 domains
- 2qqk, 2qql - hNRP-2 A2+B1+B2 domains + semaphorin-blocking antibody
- 5dn2 – hNRP-2 B1 domain + VEGF-A C terminal
- 6gh8 – hNRP-2 CUB domain 1 + Gp1
References
