6oc1: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6oc1 is ~~ON HOLD until Paper Publication~~

==Crystal structure of human DHODH with TAK-632==

~~Authors~~: ~~Durst~~, M.A., ~~Lavie~~, A.

== Structural highlights ==

<table><tr><td colspan='2'>[[6oc1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OC1 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OC1 FirstGlance].

~~Description~~: ~~Crystal structure~~ of ~~human DHODH~~ with ~~TAK-632~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=1SU:N-{7-CYANO-6-[4-FLUORO-3-({[3-(TRIFLUOROMETHYL)PHENYL]ACETYL}AMINO)PHENOXY]-1,3-BENZOTHIAZOL-2-YL}CYCLOPROPANECARBOXAMIDE'>1SU</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Dihydroorotate_dehydrogenase_(quinone) Dihydroorotate dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.2 1.3.5.2] </td></tr>

[[Category: Durst, M.A]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6oc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oc1 OCA], [http://pdbe.org/6oc1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6oc1 RCSB], [http://www.ebi.ac.uk/pdbsum/6oc1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6oc1 ProSAT]</td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[http://omim.org/entry/263750 263750]]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref>

== Function ==

[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Durst, M A]]

[[Category: Lavie, A]]

[[Category: Dhodh]]

[[Category: Inhibitor]]

[[Category: Oxidoreductase]]

[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

[[Category: Tak-632]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6oc1 is ON HOLD  until Paper Publication
+==Crystal structure of human DHODH with TAK-632==
+<StructureSection load='6oc1' size='340' side='right'caption='[[6oc1]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
-Authors: Durst, M.A., Lavie, A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6oc1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OC1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OC1 FirstGlance]. <br>
-Description: Crystal structure of human DHODH with TAK-632
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1SU:N-{7-CYANO-6-[4-FLUORO-3-({[3-(TRIFLUOROMETHYL)PHENYL]ACETYL}AMINO)PHENOXY]-1,3-BENZOTHIAZOL-2-YL}CYCLOPROPANECARBOXAMIDE'>1SU</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_dehydrogenase_(quinone) Dihydroorotate dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.2 1.3.5.2] </span></td></tr>
-[[Category: Durst, M.A]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6oc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oc1 OCA], [http://pdbe.org/6oc1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6oc1 RCSB], [http://www.ebi.ac.uk/pdbsum/6oc1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6oc1 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[http://omim.org/entry/263750 263750]]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Durst, M A]]
 [[Category: Lavie, A]]
+[[Category: Dhodh]]
+[[Category: Inhibitor]]
+[[Category: Oxidoreductase]]
+[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
+[[Category: Tak-632]]