6ps8: Difference between revisions
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==XFEL MT1R structure by ligand exchange from agomelatine to 2-phenylmelatonin.== | |||
<StructureSection load='6ps8' size='340' side='right'caption='[[6ps8]], [[Resolution|resolution]] 3.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6ps8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PS8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PS8 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JEY:N-[2-(5-methoxy-2-phenyl-1H-indol-3-yl)ethyl]acetamide'>JEY</scene></td></tr> | |||
[[Category: | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=YCM:S-(2-AMINO-2-OXOETHYL)-L-CYSTEINE'>YCM</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ps8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ps8 OCA], [http://pdbe.org/6ps8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ps8 RCSB], [http://www.ebi.ac.uk/pdbsum/6ps8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ps8 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/MTR1A_HUMAN MTR1A_HUMAN]] High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Batyuk, A]] | |||
[[Category: Cherezov, C]] | |||
[[Category: Gati, C]] | |||
[[Category: Han, G W]] | |||
[[Category: Ishchenko, A]] | |||
[[Category: Iwata, S]] | |||
[[Category: Joti, Y]] | |||
[[Category: Li, C]] | |||
[[Category: Liu, W]] | |||
[[Category: Moraes, I]] | |||
[[Category: Nakane, T]] | |||
[[Category: Nango, E]] | |||
[[Category: Shiriaeva, A]] | |||
[[Category: Stauch, B]] | |||
[[Category: Tanaka, R]] | |||
[[Category: Tono, K]] | |||
[[Category: Weierstall, U]] | |||
[[Category: Zatsepin, N A]] | |||
[[Category: 2-phenyl melatonin]] | |||
[[Category: Agomelatine]] | |||
[[Category: Complex-lcp method]] | |||
[[Category: Drug design]] | |||
[[Category: Gpcr]] | |||
[[Category: Lcp-sfx]] | |||
[[Category: Ligand exchange]] | |||
[[Category: Membrane protein]] | |||
[[Category: Mt1]] | |||
[[Category: Sbdd]] | |||
[[Category: Xfel]] | |||
Revision as of 11:09, 13 November 2019
XFEL MT1R structure by ligand exchange from agomelatine to 2-phenylmelatonin.
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