6rls: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rls OCA], [http://pdbe.org/6rls PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rls RCSB], [http://www.ebi.ac.uk/pdbsum/6rls PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rls ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rls OCA], [http://pdbe.org/6rls PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rls RCSB], [http://www.ebi.ac.uk/pdbsum/6rls PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rls ProSAT]</span></td></tr> | ||
</table> | </table> | ||
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== Publication Abstract from PubMed == | |||
Metal-mediated base pairs expand the repertoire of nucleic acid structures and dynamics. Here we report solution structures and dynamics of duplex DNA containing two all-natural C-Hg(II)-T metallo base pairs separated by six canonical base pairs. NMR experiments reveal a 3:1 ratio of well-resolved structures in dynamic equilibrium. The major species contains two (N3)T-Hg(II)-(N3)C base pairs in a predominantly B-form helix. The minor species contains (N3)T-Hg(II)-(N4)C base pairs and greater A-form characteristics. Ten-fold different (1)J coupling constants ((15)N,(199)Hg) are observed for (N3)C-Hg(II) (114 Hz) versus (N4)C-Hg(II) (1052 Hz) connectivities, reflecting differences in cytosine ionization and metal-bonding strengths. Dynamic interconversion between the two types of C-Hg(II)-T base pairs are coupled to a global conformational exchange between the helices. These observations inspired the design of a repetitive DNA sequence capable of undergoing a global B-to-A-form helical transition upon adding Hg(II), demonstrating that C-Hg(II)-T has unique switching potential in DNA-based materials and devices. | |||
Concerted dynamics of metallo-base pairs in an A/B-form helical transition.,Schmidt OP, Jurt S, Johannsen S, Karimi A, Sigel RKO, Luedtke NW Nat Commun. 2019 Oct 23;10(1):4818. doi: 10.1038/s41467-019-12440-x. PMID:31645548<ref>PMID:31645548</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
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== References == | |||
<references/> | |||
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</StructureSection> | </StructureSection> | ||
