1m55

Catalytic domain of the Adeno Associated Virus type 5 Rep protein

spinqualitylabelsall models 1m55, resolution 1.40Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1m55 is a 2 chain structure with sequence from Adeno-associated virus - 5. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CL, ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Adeno-associated virus (AAV), unique among animal viruses in its ability to integrate into a specific chromosomal location, is a promising vector for human gene therapy. AAV Replication (Rep) protein is essential for viral replication and integration, and its amino terminal domain possesses site-specific DNA binding and endonuclease activities required for replication initiation and integration. This domain displays a novel endonuclease fold and demonstrates an unexpected structural relationship to other viral origin binding proteins such as the papillomavirus E1 protein and the SV40 T antigen. The active site, located at the bottom of a positively charged cleft, is formed by the spatial convergence of a divalent metal ion and two conserved sequence motifs that define the rolling circle replication superfamily. Structural unity among viral origin binding proteins: crystal structure of the nuclease domain of adeno-associated virus Rep.,Hickman AB, Ronning DR, Kotin RM, Dyda F Mol Cell. 2002 Aug;10(2):327-37. PMID:12191478 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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