Sandbox GGC14: Difference between revisions
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== Function == | == Function == | ||
Fibrinogen is an essential protein in the coagulation, which is initiated through either an intrinsic or extrinsic pathway. Both pathways trigger a cascade of reactions that lead to the formation of a blood clot. At some point the protease thrombin is activated, thrombin then converts fibrinogen to fibrin. It does this by cleaving both the fibrinopeptide A and B off of the amino terminus of the alpha and beta chains. The alpha and beta knobs will bind to | Fibrinogen is an essential protein in the coagulation, which is initiated through either an intrinsic or extrinsic pathway. Both pathways trigger a cascade of reactions that lead to the formation of a blood clot. At some point the protease thrombin is activated, thrombin then converts fibrinogen to fibrin. It does this by cleaving both the <scene name='78/781216/Fribrinopeptide_a_and_b/3'>fibrinopeptide A and B</scene> off of the amino terminus of the alpha and beta chains. The alpha and beta knobs will bind to <scene name='78/781216/Aandb_modules/1'>a and b holes</scene> of other fibrin molecules making a fibrin mesh strong enough to hold the platelet plug. | ||
αγβ | αγβ | ||
== Disease == | == Disease == | ||
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<scene name='78/781216/Abysubunitsrbg/5'>three non-identical chains</scene> | <scene name='78/781216/Abysubunitsrbg/5'>three non-identical chains</scene> | ||
<scene name='78/781216/Fribrinopeptide_a_and_b/3'> | <scene name='78/781216/Fribrinopeptide_a_and_b/3'>fibrinopeptide A and B</scene> | ||
<scene name='78/781216/Aandb_modules/1'> | <scene name='78/781216/Aandb_modules/1'>a and b holes</scene> | ||
<scene name='78/781216/Origfibri/1'>Fibrinogen</scene> | <scene name='78/781216/Origfibri/1'>Fibrinogen</scene> | ||
