6hgo: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The~~ entry ~~6hgo~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Crystal Structure of human IL-17F==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6hgo]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HGO OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HGO FirstGlance].

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[6hg4|6hg4]], [[6hg9|6hg9]], [[6hga|6hga]]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hgo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hgo OCA], [http://pdbe.org/6hgo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hgo RCSB], [http://www.ebi.ac.uk/pdbsum/6hgo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hgo ProSAT]</td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/IL17F_HUMAN IL17F_HUMAN]] Defects in IL17F are the cause of familial candidiasis type 6 (CANDF6) [MIM:[http://omim.org/entry/613956 613956]]. CANDF6 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.<ref>PMID:21350122</ref>

== Function ==

[[http://www.uniprot.org/uniprot/IL17F_HUMAN IL17F_HUMAN]] Stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis.

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Goepfert, A]]

[[Category: Rondeau, J M]]

[[Category: Cystine-knot]]

[[Category: Cytokine]]

[[Category: Immune system]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6hgo is ON HOLD  until Paper Publication
+==Crystal Structure of human IL-17F==
+<StructureSection load='6hgo' size='340' side='right'caption='[[6hgo]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6hgo]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HGO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HGO FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6hg4|6hg4]], [[6hg9|6hg9]], [[6hga|6hga]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hgo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hgo OCA], [http://pdbe.org/6hgo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hgo RCSB], [http://www.ebi.ac.uk/pdbsum/6hgo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hgo ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/IL17F_HUMAN IL17F_HUMAN]] Defects in IL17F are the cause of familial candidiasis type 6 (CANDF6) [MIM:[http://omim.org/entry/613956 613956]]. CANDF6 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.<ref>PMID:21350122</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/IL17F_HUMAN IL17F_HUMAN]] Stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Goepfert, A]]
+[[Category: Rondeau, J M]]
+[[Category: Cystine-knot]]
+[[Category: Cytokine]]
+[[Category: Immune system]]