6i0j: Difference between revisions
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==Crystal structure of human carbonic anhydrase I in complex with the 4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenyl sulfamate inhibitor== | |||
<StructureSection load='6i0j' size='340' side='right'caption='[[6i0j]], [[Resolution|resolution]] 1.35Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6i0j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I0J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6I0J FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GZE:[4-[[4-chloranyl-3-(trifluoromethyl)phenyl]carbamoylamino]phenyl]+sulfamate'>GZE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6i0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i0j OCA], [http://pdbe.org/6i0j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i0j RCSB], [http://www.ebi.ac.uk/pdbsum/6i0j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i0j ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/CAH1_HUMAN CAH1_HUMAN]] Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea.<ref>PMID:10550681</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Carbonate dehydratase]] | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Bozdag, M]] | [[Category: Bozdag, M]] | ||
[[Category: Chiapponi, D]] | [[Category: Chiapponi, D]] | ||
[[Category: Ferraroni, M]] | [[Category: Ferraroni, M]] | ||
[[Category: Supuran, C T]] | |||
[[Category: Carbonic anhydrase i]] | |||
[[Category: Inhibitor]] | |||
[[Category: Lyase]] | |||
Revision as of 15:16, 20 November 2019
Crystal structure of human carbonic anhydrase I in complex with the 4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenyl sulfamate inhibitor
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