6i35: Difference between revisions

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'''Unreleased structure'''


The entry 6i35 is ON HOLD  until Paper Publication
==Crystal structure of human glycine decarboxylase (P-protein) bound with pyridoxyl-glycine-5'-monophosphate==
 
<StructureSection load='6i35' size='340' side='right'caption='[[6i35]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
Authors: Van Laer, B., Kapp, U., Leonard, G., Mueller-Dieckmann, C.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6i35]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I35 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6I35 FirstGlance]. <br>
Description: Crystal structure of human glycine decarboxylase (P-protein) bound with pyridoxyl-glycine-5'-monophosphate
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PLG:N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE]'>PLG</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6i33|6i33]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine_dehydrogenase_(decarboxylating) Glycine dehydrogenase (decarboxylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.4.2 1.4.4.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6i35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i35 OCA], [http://pdbe.org/6i35 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i35 RCSB], [http://www.ebi.ac.uk/pdbsum/6i35 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i35 ProSAT]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/GCSP_HUMAN GCSP_HUMAN]] Atypical glycine encephalopathy;Infantile glycine encephalopathy;Neonatal glycine encephalopathy. The disease is caused by mutations affecting the gene represented in this entry.  
== Function ==
[[http://www.uniprot.org/uniprot/GCSP_HUMAN GCSP_HUMAN]] The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH).<ref>PMID:1993704</ref> <ref>PMID:1996985</ref> <ref>PMID:28244183</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Kapp, U]]
[[Category: Kapp, U]]
[[Category: Van Laer, B]]
[[Category: Laer, B Van]]
[[Category: Leonard, G]]
[[Category: Mueller-Dieckmann, C]]
[[Category: Mueller-Dieckmann, C]]
[[Category: Leonard, G]]
[[Category: Glycine cleavage system p-protein]]
[[Category: Glycine decarboxylase]]
[[Category: Mitochondrial]]
[[Category: Oxidoreductase]]
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