6mqk: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Crystal Structure of GTPase Domain of Human Septin 12 in complex with GDP== | |||
<StructureSection load='6mqk' size='340' side='right'caption='[[6mqk]], [[Resolution|resolution]] 2.19Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6mqk]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MQK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MQK FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mqk OCA], [http://pdbe.org/6mqk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mqk RCSB], [http://www.ebi.ac.uk/pdbsum/6mqk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mqk ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/SEP12_HUMAN SEP12_HUMAN]] Non-syndromic male infertility due to sperm motility disorder. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/SEP12_HUMAN SEP12_HUMAN]] Filament-forming cytoskeletal GTPase (By similarity). Involved in spermatogenesis. Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating the association with alpha- and beta-tubulins (PubMed:24213608). Forms a filamentous structure with SEPTIN7, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). May play a role in cytokinesis (Potential).<ref>PMID:24213608</ref> <ref>PMID:25588830</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Brandao-Neto, J]] | [[Category: Brandao-Neto, J]] | ||
[[Category: Garratt, R | [[Category: Castro, D K.S V]] | ||
[[Category: Pereira, H | [[Category: Garratt, R C]] | ||
[[Category: | [[Category: Pereira, H M]] | ||
[[Category: | [[Category: Ulian, A P.U]] | ||
[[Category: Cytoskeleton component septin gtpase spermatogenesis]] | |||
[[Category: Structural protein]] | |||
Revision as of 15:24, 20 November 2019
Crystal Structure of GTPase Domain of Human Septin 12 in complex with GDP
| ||||||||||||
