6uh5: Difference between revisions
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==Structural basis of COMPASS eCM recognition of the H2Bub nucleosome== | |||
<StructureSection load='6uh5' size='340' side='right'caption='[[6uh5]], [[Resolution|resolution]] 3.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6uh5]] is a 19 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UH5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UH5 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6uh5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uh5 OCA], [http://pdbe.org/6uh5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6uh5 RCSB], [http://www.ebi.ac.uk/pdbsum/6uh5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6uh5 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/SET1_KLULA SET1_KLULA]] Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation. [[http://www.uniprot.org/uniprot/H4_XENLA H4_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Histone-lysine N-methyltransferase]] | |||
[[Category: Large Structures]] | |||
[[Category: Hsu, P L]] | |||
[[Category: Shi, H]] | |||
[[Category: Zheng, N]] | |||
[[Category: Chromatin]] | |||
[[Category: Complex]] | |||
[[Category: Epigenetic]] | |||
[[Category: Methyltransferase]] | |||
[[Category: Transferase-structural protein-dna complex]] | |||
Revision as of 15:41, 20 November 2019
Structural basis of COMPASS eCM recognition of the H2Bub nucleosome
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