Sandbox GGC7: Difference between revisions

Line 23:

== Structural highlights ==

The structure on the scene is the E28A mutant of the HIV-1 Capsid protein. The green balls are the Cl ion and the purple are Iodide ions. The structure was loaded and the color was changed to model the 6 chains connected together by a flexible linker to form the hexamers which encloses the viral RNA.

Mutant of the HIV-1 Capsid p.The structure on the scene is the E28A mutant of the HIV-1 Capsid protein. The green balls are the Cl ion and the purple are Iodide ions. The structure was loaded and the color was changed to model the 6 chains connected together by a flexible linker to form the hexamers which encloses the viral RNA.

Scene two structural highlights

Spacefill mutant HIV-1, the image displays the 6 proteins connected forming the hexamer and the N terminal domain pocket in the center this is important because is not a crucial binding site and displays low backbone deformation and mobility and shows less hydrogen binding which makes it a good target area to create an antiviral inhibitor.

Scene three structural highlights

Ca Hexamer interfaces, this is the image of the backbone of the inner surface of the CA, that is formed by two neighboring CA N- terminal domain interface pocked and is capped at one end by the R18 sidechains and by interaction of the E28-K30 on the other end. The two side chains are slightly separated that it is difficult to form hydrogen bonding. This led to explore the identification of sensitive interactions of the CA interfaces using biochemical analysis that lead to develop new antivirals targeting the stability of CA assemblies.

Sandbox GGC7: Difference between revisions

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 23: / Line 23: @@
 == Structural highlights ==
-The structure on the scene is the E28A mutant of the HIV-1 Capsid protein. The green balls are the Cl ion and the purple are Iodide ions. The structure was loaded and the color was changed to model the 6 chains connected together by a flexible linker to form the hexamers which encloses the viral RNA.
+Mutant of the HIV-1 Capsid p.The structure on the scene is the E28A mutant of the HIV-1 Capsid protein. The green balls are the Cl ion and the purple are Iodide ions. The structure was loaded and the color was changed to model the 6 chains connected together by a flexible linker to form the hexamers which encloses the viral RNA.
+Scene two structural highlights
+Spacefill mutant HIV-1, the image displays the 6 proteins connected forming the hexamer and the N terminal domain pocket in the center this is important because is not a crucial binding site and displays low backbone deformation and mobility and shows less hydrogen binding which makes it a good target area to create an antiviral inhibitor.
+Scene three structural highlights
+Ca Hexamer interfaces, this is the image of the backbone of the inner surface of the CA, that is formed by two neighboring CA N- terminal domain interface pocked and is capped at one end by the R18 sidechains and by interaction of the E28-K30 on the other end. The two side chains are  slightly separated that it is difficult to form hydrogen bonding. This led to explore the identification of sensitive interactions of the CA interfaces using biochemical analysis that lead to develop new antivirals targeting the stability of CA assemblies.