Potassium Channel: Difference between revisions

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See also [[Potassium channel Xavier]]<br />
See also [[Potassium channel Xavier]]<br />
[[Eag domain-CNBHD complex of the mouse EAG1]].
[[Eag domain-CNBHD complex of the mouse EAG1]].
</StructureSection>


==Page Development==
==Page Development==
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'''Potassium channels''' (KCh) are subdivided into voltage-gated KCh and calcium-dependent KCh.  The latter are subdivided into high- (BK, LKCa), intermediate- and small-conductance KCh (human SK1, rat SK2, SKCa).  The T1 domain is a highly conserved N-terminal domain which is responsible for driving the tetramerization of the KCh α subunit.  The inward rectifier KCh (IRK) passes current more easily in the inward direction.  MthK is a calcium-dependent KCh from ''Methanobacterium thermoautrophicum''.
'''Potassium channels''' (KCh) are subdivided into voltage-gated KCh and calcium-dependent KCh.  The latter are subdivided into high- (BK, LKCa), intermediate- and small-conductance KCh (human SK1, rat SK2, SKCa).  The T1 domain is a highly conserved N-terminal domain which is responsible for driving the tetramerization of the KCh α subunit.  The inward rectifier KCh (IRK) passes current more easily in the inward direction.  MthK is a calcium-dependent KCh from ''Methanobacterium thermoautrophicum''.
== 3D structures of Potassium Channels==
[[Potassium channel 3D structures]]
</StructureSection>


== 3D structures of Potassium Channels==
== 3D structures of Potassium Channels==
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*Potassium Channel
*Potassium Channel


**[[2pnv]] – rKCh leucine zipper domain SKCa – rat<br />
**[[3lut]] - rKCh Kv1.2 (mutant) <br />
**[[1dsx]] - rKCh N-terminal (mutant)<br />
**[[1qdv]], [[1qdw]] - rKCh Kv1.2 N-terminal<br />
**[[1kn7]] - rKCh Kv1.4 N-terminal (mutant) - NMR<br />
**[[1nn7]] - rKCh Kv4.2 N-terminal T1 domain<br />
**[[5wie]] - rKCh β-2 (mutant)<br />
**[[3eau]] - rKCh β-2 +cortisone<br />
**[[3eb3]], [[3eb4]] - rKCh β-2 (mutant) + cortisone<br />
**[[4hoi]] – mKCh Kv10.1 PAS domain – mouse<br />
**[[4llo]] – mKCh EAG1 <br />
**[[5u76]], [[5u70]], [[5a6g]], [[5a6f]], [[5a6e]] – cKCh SLO2.2 – chicken – CryoEM<br />
**[[1wlj]], [[2wlh]], [[2wli]], [[2wlj]], [[2wlm]], [[2wln]], [[2wlo]] - MmKCh - ''Magnetospirillum magnetoacticum''<br />
**[[1wlj]], [[2wlh]], [[2wli]], [[2wlj]], [[2wlm]], [[2wln]], [[2wlo]] - MmKCh - ''Magnetospirillum magnetoacticum''<br />
**[[2k44]] – KCh voltage-sensor paddle domain – NMR<br />
**[[2k44]] – KCh voltage-sensor paddle domain – NMR<br />
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**[[1jq1]], [[1jq2]] - SlKCh Kcsa inner transmembrane segment - NMR<br />
**[[1jq1]], [[1jq2]] - SlKCh Kcsa inner transmembrane segment - NMR<br />
**[[3ifx]] - SlKCh Kcsa pore domain<br />
**[[3ifx]] - SlKCh Kcsa pore domain<br />
**[[2pnv]] – rKCh leucine zipper domain SKCa – rat<br />
**[[3lut]] - rKCh Kv1.2 (mutant) <br />
**[[1dsx]] - rKCh N-terminal (mutant)<br />
**[[1qdv]], [[1qdw]] - rKCh Kv1.2 N-terminal<br />
**[[1kn7]] - rKCh Kv1.4 N-terminal (mutant) - NMR<br />
**[[1nn7]] - rKCh Kv4.2 N-terminal T1 domain<br />
**[[5wie]] - rKCh β-2 (mutant)<br />
**[[3eau]] - rKCh β-2 +cortisone<br />
**[[3eb3]], [[3eb4]] - rKCh β-2 (mutant) + cortisone<br />
**[[4hoi]] – mKCh Kv10.1 PAS domain – mouse<br />
**[[4llo]] – mKCh EAG1 <br />
**[[1a68]], [[1eod]], [[1eoe]], [[1eof]], [[3kvt]] - AcKCh Kv1.1 T1 domain (mutant) - ''Aplysia californica''<br />
**[[1a68]], [[1eod]], [[1eoe]], [[1eof]], [[3kvt]] - AcKCh Kv1.1 T1 domain (mutant) - ''Aplysia californica''<br />
**[[1t1d]] - AcKCh Kv1.1 T1 domain<br />
**[[1t1d]] - AcKCh Kv1.1 T1 domain<br />
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**[[2wll]] - KCh KIRBAC1.1 - ''Burkholderia pseudomalie''<br />
**[[2wll]] - KCh KIRBAC1.1 - ''Burkholderia pseudomalie''<br />
**[[1bei]] - KCh Kv1.3 – ''Stichodactyla helianthus''<br />
**[[1bei]] - KCh Kv1.3 – ''Stichodactyla helianthus''<br />
**[[5u76]], [[5u70]], [[5a6g]], [[5a6f]], [[5a6e]] – cKCh SLO2.2 – chicken – CryoEM<br />


*Potassium channel complex with protein
*Potassium channel complex with protein


**[[2nz0]] – hKCh Kv4.3 N-terminal+KV channel interacting protein 1 <br />
**[[2i2r]] - rKCh Kv4.3 N-terminal+KV channel interacting protein 1<br />
**[[2i2r]] - rKCh Kv4.3 N-terminal+KV channel interacting protein 1<br />
**[[1s6c]] - rKCh Kv4.2 N-terminal+KV channel interacting protein 1<br />
**[[1s6c]] - rKCh Kv4.2 N-terminal+KV channel interacting protein 1<br />
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**[[3f7v]], [[3f7y]], [[3fb5]], [[3fb7]], [[3fb8]], [[3gb7]], [[3hpl]], [[3iga]], [[3or6]], [[3or7]], [[1r3i]], [[1r3j]], [[1r3k]],[[1r3l]], [[1s5h]], [[2atk]], [[2bob]], [[2boc]], [[2dwd]], [[2dwe]], [[2hvj]], [[2hvk]], [[2ih1]], [[2ih3]], [[2itc]], [[2itd]], [[2jk5]], [[2nlj]] - mKCh (mutant) + FAB<br />
**[[3f7v]], [[3f7y]], [[3fb5]], [[3fb7]], [[3fb8]], [[3gb7]], [[3hpl]], [[3iga]], [[3or6]], [[3or7]], [[1r3i]], [[1r3j]], [[1r3k]],[[1r3l]], [[1s5h]], [[2atk]], [[2bob]], [[2boc]], [[2dwd]], [[2dwe]], [[2hvj]], [[2hvk]], [[2ih1]], [[2ih3]], [[2itc]], [[2itd]], [[2jk5]], [[2nlj]] - mKCh (mutant) + FAB<br />
**[[3f5w]], [[1zwi]], [[2hjf]] - mKCh (mutant) + antibody heavy+light chains<br />
**[[3f5w]], [[1zwi]], [[2hjf]] - mKCh (mutant) + antibody heavy+light chains<br />
**[[5vms]] - KCh Kv7.1 + calmodulin - frog <br />
**[[1k4c]], [[1k4d]], [[4lcu]], [[5ec2]], [[5ec1]], [[5ebw]], [[5ebm]], [[5ebl]], [[5e1a]], [[4lbe]] - SlKCh Kcsa (mutant) + antibody <br />
**[[1k4c]], [[1k4d]], [[4lcu]], [[5ec2]], [[5ec1]], [[5ebw]], [[5ebm]], [[5ebl]], [[5e1a]], [[4lbe]] - SlKCh Kcsa (mutant) + antibody <br />
**[[3pjs]], [[5j9p]], [[4uuj]], [[4msw]], [[4lbe]], [[5vkh]], [[5vke]], [[5vk6]]  – SlKCh Kcsa + antibody<br />
**[[3pjs]], [[5j9p]], [[4uuj]], [[4msw]], [[4lbe]], [[5vkh]], [[5vke]], [[5vk6]]  – SlKCh Kcsa + antibody<br />
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**[[2a0l]] - AeKCh + FV<br />
**[[2a0l]] - AeKCh + FV<br />
**[[1orq]] - AeKCh (mutant) + FAB<br />
**[[1orq]] - AeKCh (mutant) + FAB<br />
**[[5vms]] - KCh Kv7.1 + calmodulin - frog <br />
**[[5hu3]], [[5h9b]], [[5fg8]] - DmKCh EAG + CAMKII  <br />
**[[5hu3]], [[5h9b]], [[5fg8]] - DmKCh EAG + CAMKII  <br />


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**[[2l1m]], [[2l4r]], [[2l0w]] - hKCh HERG - NMR<br />
**[[2l1m]], [[2l4r]], [[2l0w]] - hKCh HERG - NMR<br />
**[[1s1g]] - hKCh Kv4.3 T1 domain<br />
**[[1s1g]] - hKCh Kv4.3 T1 domain<br />
**[[2nz0]] – hKCh Kv4.3 N-terminal+KV channel interacting protein 1 <br />
**[[2ovc]] - hKCh Kv7.4 T1 domain<br />
**[[2ovc]] - hKCh Kv7.4 T1 domain<br />
**[[3bj4]] - hKCh Kv7.1 C-termianl<br />
**[[3bj4]] - hKCh Kv7.1 C-termianl<br />
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*Inward rectifier KCh
*Inward rectifier KCh


**[[6c3p]], [[6c3o]] - hIRK 11 + sulfonylurea receptor + ATP + ADP – Cryo EM<br />
**[[6baa]] - hIRK 11 + sulfonylurea receptor + ATP + glibenclamide – Cryo EM<br />
**[[3ukm]] – hIRK TWIK-1<br />
**[[3um7]] – hIRK TRAAK<br />
**[[4ruf]], [[4rue]] - hIRK TRAAK (mutant)<br />
**[[4wfh]], [[4wfg]], [[4wfe]], [[4wff]] - hIRK TRAAK + antibody<br />
**[[4i9w]] - hIRK TRAAK (mutant) + antibody<br />
**[[5twv]] - rIRK 11 + sulfonylurea receptor + ATP + glibenclamide – Cryo EM<br />
**[[1u4f]],[[3agw]] - mIRK 2 cytoplasmic domain<br />
**[[1u4f]],[[3agw]] - mIRK 2 cytoplasmic domain<br />
**[[2xky]] - mIRK 2 cytoplasmic domain - EM<br />
**[[2xky]] - mIRK 2 cytoplasmic domain - EM<br />
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**[[5ywc]], [[5ywb]] - mIRK 11 + sulfonylurea receptor + ADP – Cryo EM<br />
**[[5ywc]], [[5ywb]] - mIRK 11 + sulfonylurea receptor + ADP – Cryo EM<br />
**[[5ywa]], [[5yw9]], [[5yw8]] - mIRK 11 + sulfonylurea receptor + ATP – Cryo EM<br />
**[[5ywa]], [[5yw9]], [[5yw8]] - mIRK 11 + sulfonylurea receptor + ATP – Cryo EM<br />
**[[6c3p]], [[6c3o]] - hIRK 11 + sulfonylurea receptor + ATP + ADP – Cryo EM<br />
**[[6baa]] - hIRK 11 + sulfonylurea receptor + ATP + glibenclamide – Cryo EM<br />
**[[5twv]] - rIRK 11 + sulfonylurea receptor + ATP + glibenclamide – Cryo EM<br />
**[[5ykg]], [[5ykf]], [[5yke]] - mIRK 11 + sulfonylurea receptor + ATP + glibenclamide – Cryo EM<br />
**[[5ykg]], [[5ykf]], [[5yke]] - mIRK 11 + sulfonylurea receptor + ATP + glibenclamide – Cryo EM<br />
**[[1xl4]], [[1xl6]], [[2wlk]], [[2x6a]], [[2x6b]], [[2x6c]] - MmIRK KIRBAC3.1<br />
**[[4lp8]] - MmIRK KIRBAC3.1 (mutant) <br />
**[[1p7b]] - BpIRK C-terminal<br />
**[[3spc]] – cIRK 2.2 + DGPP <br />
**[[3spc]] – cIRK 2.2 + DGPP <br />
**[[3spg]], [[3sph]], [[5kum]], [[5kuk]]  – cIRK 2.2 (mutant) + PIP2<br />
**[[3spg]], [[3sph]], [[5kum]], [[5kuk]]  – cIRK 2.2 (mutant) + PIP2<br />
**[[3spi]] – cIRK 2.2 + PIP2<br />
**[[3spi]] – cIRK 2.2 + PIP2<br />
**[[3spj]] – cIRK 2.2 (mutant)<br />
**[[3spj]] – cIRK 2.2 (mutant)<br />
**[[3ukm]] – hIRK TWIK-1<br />
**[[1xl4]], [[1xl6]], [[2wlk]], [[2x6a]], [[2x6b]], [[2x6c]] - MmIRK KIRBAC3.1<br />
**[[3um7]] – hIRK TRAAK<br />
**[[4lp8]] - MmIRK KIRBAC3.1 (mutant) <br />
**[[4ruf]], [[4rue]] - hIRK TRAAK (mutant)<br />
**[[3zrs]] – MmIRK 10<br />
**[[4wfh]], [[4wfg]], [[4wfe]], [[4wff]] - hIRK TRAAK + antibody<br />
**[[1p7b]] - BpIRK C-terminal<br />
**[[4i9w]] - hIRK TRAAK (mutant) + antibody<br />
**[[3zrs]] – MmIRK 10


*Outward rectifier KCh
*Outward rectifier KCh
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*Small conductance calcium-activated KCh; Domains - calmodulin-binding 395-487; leucine zipper 488-526
*Small conductance calcium-activated KCh; Domains - calmodulin-binding 395-487; leucine zipper 488-526


**[[6ale]], [[5v03]], [[5v02]] - hKCh SKCa2 calmodulin-binding domain + calmodulin<br />
**[[5wc5]], [[5wbx]] - hKCh SKCa2 calmodulin-binding domain (mutant) + calmodulin<br />
**[[1kkd]] – rKCh calmodulin-binding domain - NMR <br />
**[[1kkd]] – rKCh calmodulin-binding domain - NMR <br />
**[[3sjq]], [[4g27]], [[4g28]], [[4j9y]], [[4j9z]], [[1g4y]], [[4qnh]], [[1qx7]], [[6czq]] - rKCh calmodulin-binding domain + calmodulin<br />
**[[3sjq]], [[4g27]], [[4g28]], [[4j9y]], [[4j9z]], [[1g4y]], [[4qnh]], [[1qx7]], [[6czq]] - rKCh calmodulin-binding domain + calmodulin<br />
**[[2pnv]] – rKCh leucine zipper domain SKCa <br />
**[[2pnv]] – rKCh leucine zipper domain SKCa <br />
**[[6ale]], [[5v03]], [[5v02]] - hKCh SKCa2 calmodulin-binding domain + calmodulin<br />
**[[5wc5]], [[5wbx]] - hKCh SKCa2 calmodulin-binding domain (mutant) + calmodulin<br />


*Intermediate conductance calcium-activated KCh
*Intermediate conductance calcium-activated KCh
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