6m8q: Difference between revisions

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'''Unreleased structure'''


The entry 6m8q is ON HOLD until Paper Publication
==Cleavage and Polyadenylation Specificity Factor Subunit 3 (CPSF3) in complex with NVP-LTM531==
 
<StructureSection load='6m8q' size='340' side='right'caption='[[6m8q]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6m8q]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M8Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6M8Q FirstGlance]. <br>
Description:  
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JBG:N-{3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzene-1-carbonyl}-L-phenylalanine'>JBG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6m8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m8q OCA], [http://pdbe.org/6m8q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6m8q RCSB], [http://www.ebi.ac.uk/pdbsum/6m8q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6m8q ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/CPSF3_HUMAN CPSF3_HUMAN]] Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3'-end-processing endonuclease. Also involved in the histone 3'-end pre-mRNA processing. U7 snRNP-dependent protein that induces both the 3'-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' to 3' exonuclease for degrading the subsequent downstream cleavage product (DCP) of mature histone mRNAs. Cleavage occurs after the 5'-ACCCA-3' sequence in the histone pre-mRNA leaving a 3'hydroxyl group on the upstream fragment containing the stem loop (SL) and 5' phosphate on the downstream cleavage product (DCP) starting with CU nucleotides. The U7-dependent 5' to 3' exonuclease activity is processive and degrades the DCP RNA substrate even after complete removal of the U7-binding site. Binds to the downstream cleavage product (DCP) of histone pre-mRNAs and the cleaved DCP RNA substrate in a U7 snRNP dependent manner.<ref>PMID:14749727</ref> <ref>PMID:15037765</ref> <ref>PMID:18688255</ref> <ref>PMID:17128255</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Michaud, G]]
[[Category: Salcius, M]]
[[Category: Weihofen, W A]]
[[Category: Artemi]]
[[Category: Double-strand break repair]]
[[Category: Hydrolase]]
[[Category: Hydroxylase]]
[[Category: Metallo-b-lactamase]]
[[Category: Polyadenylation]]
[[Category: Pre-mrna processing]]
[[Category: Rna binding protein]]
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