6mxz: Difference between revisions
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==Structure of 53BP1 Tudor domains in complex with small molecule UNC3474== | |||
<StructureSection load='6mxz' size='340' side='right'caption='[[6mxz]], [[Resolution|resolution]] 2.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6mxz]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MXZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MXZ FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=K6S:N-[3-(tert-butylamino)propyl]-3-(propan-2-yl)benzamide'>K6S</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mxz OCA], [http://pdbe.org/6mxz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mxz RCSB], [http://www.ebi.ac.uk/pdbsum/6mxz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mxz ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Botuyan, M V]] | |||
[[Category: Cui, G]] | |||
[[Category: Mer, G]] | |||
[[Category: Schuller, D J]] | |||
[[Category: Dna damage response]] | |||
[[Category: Protein binding]] | |||
[[Category: Small molecule inhibitor]] | |||
[[Category: Tudor domain]] | |||
Revision as of 06:49, 27 November 2019
Structure of 53BP1 Tudor domains in complex with small molecule UNC3474
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