6n55: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6n55 is ~~ON HOLD until Nov 21 2020~~

==Crystal structure of human uridine-cytidine kinase 2 complexed with 2'-azidouridine==

~~Authors~~: ~~Cuthbert~~, B.J., ~~Nainar~~, S., ~~Spitale~~, R.C., ~~Goulding, C~~.W.

== Structural highlights ==

<table><tr><td colspan='2'>[[6n55]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N55 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N55 FirstGlance].

~~Description~~: ~~Crystal structure of human~~ uridine-~~cytidine kinase~~ 2 ~~complexed with 2'~~-~~azidouridine~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=UZ0:2-azido-2-deoxyuridine'>UZ0</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Uridine_kinase Uridine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.48 2.7.1.48] </td></tr>

[[Category: Cuthbert, B.J]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n55 OCA], [http://pdbe.org/6n55 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n55 RCSB], [http://www.ebi.ac.uk/pdbsum/6n55 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n55 ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/UCK2_HUMAN UCK2_HUMAN]] Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine.

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Uridine kinase]]

[[Category: Cuthbert, B J]]

[[Category: Goulding, C W]]

[[Category: Nainar, S]]

[[Category: ~~Goulding~~, C.W]]

[[Category: Spitale, R C]]

[[Category: ~~Spitale, R.C~~]]

[[Category: Azide]]

[[Category: Complex]]

[[Category: Cytosolic protein]]

[[Category: Kinase]]

[[Category: Uck2]]

[[Category: Uridine-cytidine kinase 2]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6n55 is ON HOLD  until Nov 21 2020
+==Crystal structure of human uridine-cytidine kinase 2 complexed with 2'-azidouridine==
+<StructureSection load='6n55' size='340' side='right'caption='[[6n55]], [[Resolution|resolution]] 3.08&Aring;' scene=''>
-Authors: Cuthbert, B.J., Nainar, S., Spitale, R.C., Goulding, C.W.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6n55]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N55 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N55 FirstGlance]. <br>
-Description: Crystal structure of human uridine-cytidine kinase 2 complexed with 2'-azidouridine
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=UZ0:2-azido-2-deoxyuridine'>UZ0</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Uridine_kinase Uridine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.48 2.7.1.48] </span></td></tr>
-[[Category: Cuthbert, B.J]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n55 OCA], [http://pdbe.org/6n55 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n55 RCSB], [http://www.ebi.ac.uk/pdbsum/6n55 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n55 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/UCK2_HUMAN UCK2_HUMAN]] Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine.
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Uridine kinase]]
+[[Category: Cuthbert, B J]]
+[[Category: Goulding, C W]]
 [[Category: Nainar, S]]
-[[Category: Goulding, C.W]]
+[[Category: Spitale, R C]]
-[[Category: Spitale, R.C]]
+[[Category: Azide]]
+[[Category: Complex]]
+[[Category: Cytosolic protein]]
+[[Category: Kinase]]
+[[Category: Uck2]]
+[[Category: Uridine-cytidine kinase 2]]