6s4u: Difference between revisions
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==LXRbeta ligand binding domain in comlpex with small molecule inhibitors== | |||
<StructureSection load='6s4u' size='340' side='right'caption='[[6s4u]], [[Resolution|resolution]] 2.81Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6s4u]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S4U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6S4U FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KVK:6-[4-[[3-oxidanyl-1,1-bis(oxidanylidene)-5-phenyl-2-propan-2-yl-3~{H}-1,2-thiazol-4-yl]amino]butyl]pyridine-2-sulfonamide'>KVK</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6s4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s4u OCA], [http://pdbe.org/6s4u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s4u RCSB], [http://www.ebi.ac.uk/pdbsum/6s4u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s4u ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/NR1H2_HUMAN NR1H2_HUMAN]] Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Jansson, A]] | [[Category: Jansson, A]] | ||
[[Category: Sandmark, J]] | [[Category: Sandmark, J]] | ||
[[Category: Liver x receptor beta lxrb lxr beta nuclear hormone receptor receptor ligand binding domain]] | |||
[[Category: Nuclear protein]] | |||
Revision as of 06:57, 27 November 2019
LXRbeta ligand binding domain in comlpex with small molecule inhibitors
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